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Jason C. Park, Xian Zhang, John Ferrera, Joy Hirsch, Donald C. Hood; Comparison of contrast-response functions from multifocal visual-evoked potentials (mfVEPs) and functional MRI responses. Journal of Vision 2008;8(10):8. doi: 10.1167/8.10.8.
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Contrast response functions (CRFs) from multifocal visual-evoked potential (mfVEP) and BOLD fMRI responses were obtained using the same stimuli to test the hypothesis of a linear relationship between the mfVEP and BOLD fMRI responses. Monocular mfVEP and BOLD fMRI responses were obtained using an 8° in diameter, dartboard pattern stimulus with reversing checkerboards. Six contrast conditions (4%, 8%, 16%, 32%, 64%, and 90%) were run. The mfVEP, largely generated in V1, was compared to the BOLD fMRI signal from V1 and extrastriate cortex. Retinotopic maps of each subject were acquired and used to localize the V1 area. For all subjects, the CRFs for the mfVEPs and BOLD fMRI responses showed good agreement, suggesting that they both share the same functional relationship with underlying neural activity. In particular, this result is consistent with the assumption that the relationship between the BOLD response and underlying neural activity is linear, although the particular linear model proposed by D. J. Heeger, A. C. Huk, W. S. Geisler, and D. G. Albrecht (2000) does not fit the results.
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