June 2004
Volume 4, Issue 8
Free
Vision Sciences Society Annual Meeting Abstract  |   August 2004
Retinal image motion abolishes the EEG evoked by pattern reversal, but not by onset
Author Affiliations
  • Michael Bach
    Electrophysiology Lab, Universitäts-Augenklinik Freiburg, Germany
  • Petra S. Seufert
    Visual Processing Lab, Universitäts-Augenklinik Freiburg, Germany
  • Michael B. Hoffmann
    Visual Processing Lab, Universitäts-Augenklinik Freiburg, Germany
Journal of Vision August 2004, Vol.4, 745. doi:10.1167/4.8.745
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      Michael Bach, Petra S. Seufert, Michael B. Hoffmann; Retinal image motion abolishes the EEG evoked by pattern reversal, but not by onset. Journal of Vision 2004;4(8):745. doi: 10.1167/4.8.745.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose. In patients with nystagmus the functional assessment with visual evoked potentials (VEPs) is severely impeded. Specifically, pattern-reversal responses are strongly reduced or absent in nystagmus patients, while pattern-onset responses can often still be obtained. To quantitatively assess the differential effect of retinal image slip on pattern-reversal and pattern-onset responses we simulated different degrees of nystagmus in normal subjects. Methods. In eight subjects we monitored eye-movements and recorded pattern-reversal and pattern-onset VEPs from occipital electrodes. Subjects viewed the stimulus via a mirror, which was placed close to the eye and driven by a scanner at four different amplitudes of a 4-Hz sawtooth waveform at 0, 1, 2, and 3 of amplitude. Results. Retinal image motion nearly abolished the pattern-reversal VEPs (by up to 85%; p<0.001), while there was no significant effect on pattern-onset VEPs. No oculomotor activity was induced by nystagmus-like retinal image slip at 4 Hz, in contrast to a control condition with slower motion (1 Hz) which induced marked eye movements. Conclusion. The strong differential effect of simulated nystagmus on pattern-reversal and pattern-onset VEPs indicates that the spatio-temporal properties of the pattern-reversal stimulus are sufficient to explain its low efficacy in patients with nystagmus. For clinical applications, it follows that pattern-onset is the preferred stimulation-mode in patients with oculomotor instabilities. Of the various possible explanations we quantitatively argue for a mechanism based on motion adaptation.

DFG HO-2002/3-1

Bach, M., Seufert, P. S., Hoffmann, M. B.(2004). Retinal image motion abolishes the EEG evoked by pattern reversal, but not by onset [Abstract]. Journal of Vision, 4( 8): 745, 745a, http://journalofvision.org/4/8/745/, doi:10.1167/4.8.745. [CrossRef]
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