June 2004
Volume 4, Issue 8
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Vision Sciences Society Annual Meeting Abstract  |   August 2004
Collicular Involvement in Macro-Square-Wave Eye Jerks in an Experimental Rhesus Monkey
Author Affiliations
  • James Gnadt
    Stony Brook University, USA
Journal of Vision August 2004, Vol.4, 766. doi:10.1167/4.8.766
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      James Gnadt, Dana Carasig, Eion Ramcharan, Michele Bookbinder, Kush Paul; Collicular Involvement in Macro-Square-Wave Eye Jerks in an Experimental Rhesus Monkey. Journal of Vision 2004;4(8):766. doi: 10.1167/4.8.766.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Though eye jerk syndromes are sometimes associated with identifiable cerebellar deficits or multiple sclerosis, there is little definitive information on the probable causes of eye jerk syndromes in general. One viable hypothesis is that they are related to an imbalance or temporal mismatch between excitatory and inhibitory drive within the saccadic circuit. From the spontaneous occurrence of ocular eye jerks in an experimental Rhesus monkey we were able to determine the neurologic and anatomic etiology of the syndrome. Despite hypotheses implicating the loss of inhibitory tone from the saccadic omnipause neurons, we found no structural damage to the raphe interpositus. Examination of the cerebellum was also normal. Instead, we found a midline cerebrovascular accident in the tectum that spread bilaterally into both superior colliculi. This reveals the cause of this eye jerk syndrome as saccadic intrusions secondary to peculiar involvement of bilateral damage to the superior colliculi.

Gnadt, J., Carasig, D., Ramcharan, E., Bookbinder, M., Paul, K.(2004). Collicular Involvement in Macro-Square-Wave Eye Jerks in an Experimental Rhesus Monkey [Abstract]. Journal of Vision, 4( 8): 766, 766a, http://journalofvision.org/4/8/766/, doi:10.1167/4.8.766. [CrossRef]
Footnotes
 Funded by EY-08217
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