June 2004
Volume 4, Issue 8
Free
Vision Sciences Society Annual Meeting Abstract  |   August 2004
Acute and long term mferg assessment of laser induced focal and secondary retinal damage in the non-human primate
Author Affiliations
  • Harry Zwick
    Walter Reed Army Institute of Research, USA, Brooks City Base, TX
Journal of Vision August 2004, Vol.4, 773. doi:10.1167/4.8.773
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      Harry Zwick, Jeremiah Brown, Jr., Cheryl DiCarlo, David J. Lund, Bruce E. Stuck; Acute and long term mferg assessment of laser induced focal and secondary retinal damage in the non-human primate. Journal of Vision 2004;4(8):773. doi: 10.1167/4.8.773.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Laser induced retinal damage may involve primary injury to the central retina as well as secondary damage, including intraretetinal scar formation (IRSF) retinal traction (RT) and retinal nerve fiber layer injury (RNFL) within the central retina. We have evaluated these laser induced retinal pathologies with MFERG in seven non-human primates (NHPs) with a Veris (4.9) MFERG system (103 Hexagons, centered on the macula with non-scaled and scaled hexagonal arrays). Chemical restraint was achieved using Ketamine stability HCL (10 mg/kg IM) and Propofol (0.5 mg–1.2/Kg/min via syringe pump). Peribulbar eye blocks were performed using 2% lidocain or a mixture of 2% Lidocain/Marcain (monitored ocular motility was less than 40 microns in retinal space). Primary and secondary damage effects were induced with either q-switched single pulse Neodymium (1064 nm, 1.0 mJ), Argon CW (10 to 1000 msec, 10–150 mJ). MFERG demonstrated capability to detect primary and secondary induced retinal damage in both 1st and 2nd kernels. Primary and secondary damage in the central retina were often suppressed in amplitude with longer latencies relative to the MFERG norm. MFERG recovery detected in non-scaled arrays for both primary and secondary laser retinal damage revealed more central retinal deficits with scaled arrays, which emphasize the smaller neural funneling units in central retina and detectable with the level of ocular motility permitted.

Zwick, H., Brown, J.Jr., DiCarlo, C., Lund, D. J., Stuck, B. E.(2004). Acute and long term mferg assessment of laser induced focal and secondary retinal damage in the non-human primate [Abstract]. Journal of Vision, 4( 8): 773, 773a, http://journalofvision.org/4/8/773/, doi:10.1167/4.8.773. [CrossRef]
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