September 2005
Volume 5, Issue 8
Free
Vision Sciences Society Annual Meeting Abstract  |   September 2005
Occipital activations and deactivations induced by stimulation of the right human frontal eye field
Author Affiliations
  • Christian C. Ruff
    Institute of Cognitive Neuroscience & Dept. of Psychology, University College London, UK, and Wellcome Dept. of Imaging Neuroscience, University College London, UK
  • Felix Blankenburg
    Institute of Cognitive Neuroscience & Dept. of Psychology, University College London, UK, and Wellcome Dept. of Imaging Neuroscience, University College London, UK
  • Otto Bjoertomt
    Institute of Cognitive Neuroscience & Dept. of Psychology, University College London, UK
  • Sven Bestmann
    Institute of Cognitive Neuroscience & Dept. of Psychology, University College London, UK, and Wellcome Dept. of Imaging Neuroscience, University College London, UK
  • John-Dylan Haynes
    Institute of Cognitive Neuroscience & Dept. of Psychology, University College London, UK, and Wellcome Dept. of Imaging Neuroscience, University College London, UK
  • Geraint Rees
    Institute of Cognitive Neuroscience & Dept. of Psychology, University College London, UK, and Wellcome Dept. of Imaging Neuroscience, University College London, UK
  • Oliver Josephs
    Wellcome Dept. of Imaging Neuroscience, University College London, UK
  • Ralf Deichmann
    Wellcome Dept. of Imaging Neuroscience, University College London, UK
  • Jon Driver
    Institute of Cognitive Neuroscience & Dept. of Psychology, University College London, UK, and Wellcome Dept. of Imaging Neuroscience, University College London, UK
Journal of Vision September 2005, Vol.5, 365. doi:10.1167/5.8.365
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      Christian C. Ruff, Felix Blankenburg, Otto Bjoertomt, Sven Bestmann, John-Dylan Haynes, Geraint Rees, Oliver Josephs, Ralf Deichmann, Jon Driver; Occipital activations and deactivations induced by stimulation of the right human frontal eye field. Journal of Vision 2005;5(8):365. doi: 10.1167/5.8.365.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The frontal eye fields (FEF) are traditionally thought to be involved in the preparation and execution of eye movements, but more recent evidence suggests a role in covert spatial attention also. Projections from this putative control area in frontal cortex may modulate activity in visual cortex, but direct evidence for this is lacking in humans, despite recent breakthroughs in monkey studies. Here we used a combination of fMRI and Transcranial Magnetic Stimulation (TMS) in the scanner to show that stimulation of human FEF can modulate activity in retinotopically mapped visual cortex. Right FEF stimulation activated bilaterally sectors of retinotopic visual cortex (V1–V3, and beyond) that represent the peripheral visual field; but it deactivated sectors representing the central visual field. This FEF-induced retinotopic pattern did not depend on resting activation in visual cortex, as it was equivalently present with or without concurrent visual stimulation. Nor was it due to TMS-induced eye movements, blinks, or pupil changes. These data (1) provide direct support for FEF modulation of visual cortex, (2) are consistent with recent anatomical and physiological studies in other primates, which suggest distinct FEF-occipital connections for central and peripheral visual field representations, and (3) illustrate how concurrent TMS and fMRI can now be used to study functional influences between remote but interconnected brain areas.

Ruff, C. C. Blankenburg, F. Bjoertomt, O. Bestmann, S. Haynes, J.-D. Rees, G. Josephs, O. Deichmann, R. Driver, J. (2005). Occipital activations and deactivations induced by stimulation of the right human frontal eye field [Abstract]. Journal of Vision, 5(8):365, 365a, http://journalofvision.org/5/8/365/, doi:10.1167/5.8.365. [CrossRef]
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