December 2006
Volume 6, Issue 13
OSA Fall Vision Meeting Abstract  |   December 2006
Cellular mechanisms for visual adaptation
Author Affiliations
  • Jonathan Demb
    Departments of Ophthalmology & Visual Sciences, and Molecular, Cellular & Developmental Biology, University of Michigan, Ann Arbor, MI, USA
Journal of Vision December 2006, Vol.6, 1. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Jonathan Demb; Cellular mechanisms for visual adaptation. Journal of Vision 2006;6(13):1. doi:

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Visual neurons adjust their sensitivity to the immediate environment through the process of adaptation. Adaptation increases sensitivity when signals are weak, to improve the signal-to-noise ratio, and decreases sensitivity when signals are strong, to avoid response saturation. In the retina, cells adapt to the mean intensity but also to the contrast, or the range of light intensities relative to the mean. Contrast adaptation is not present at the output of photoreceptors and thus must arise within retinal circuitry. I will describe experiments in mammalian retinal ganglion cells, measured in vitro, that aim to elucidate the cellular mechanisms for contrast adaptation. A linear systems approach is used to quantify a gain change at high contrast; the analysis is robust in the presence of known nonlinearities in the subthreshold or spiking responses. When contrast triples, the gain in the spiking response reduces by about a factor of two. Intracellular measurements show that the gain change is partially an intrinsic property of the cell, related to spike generation, and partially a synaptic mechanism that arises within the presynaptic bipolar cells. Different ganglion cell types express differing degrees of adaptation, and this variation must relate to each cell type's unique pattern of intrinsic properties and synaptic connections.

Demb, J. (2006). Cellular mechanisms for visual adaptation [Abstract]. Journal of Vision, 6(13):1, 1a,, doi:10.1167/6.13.1. [CrossRef] [PubMed]

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.