December 2007
Volume 7, Issue 15
Free
OSA Fall Vision Meeting Abstract  |   December 2007
Blue-Yellow opponent receptive field structure of primate S-cones
Author Affiliations
  • Dennis Dacey
    University of Washington, Department of Biological Structure
  • Orin Packer
    University of Washington, Department of Biological Structure
  • Jan Verweij
    University of California, San Francisco
  • Julie Schnapf
    Dept. of Ophthalmology, University of California, San Francisco
Journal of Vision December 2007, Vol.7, 5. doi:10.1167/7.15.5
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Dennis Dacey, Orin Packer, Jan Verweij, Julie Schnapf; Blue-Yellow opponent receptive field structure of primate S-cones. Journal of Vision 2007;7(15):5. doi: 10.1167/7.15.5.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Previous recordings from primate long (L) and middle (M) wavelength cones reveal a receptive field surround that transmits a mixed L and M cone signal to both cone types. Thus for L and M cones there is no basis for cone type selective wiring at the level of the cone synapse. In this study we targeted the sparse S cones to test the hypothesis that S cones receive negative feedback from L and M cones. S cones were reliably identified in vitro by small inner segment diameters and physiologically with stimuli that modulated light absorption in L, M, or S cone photopigment. S cone receptive fields were characterized from spots, annuli, and drifting sinusoidal gratings that modulated either S or L+M cone responses. Under voltage clamp S cones showed not only the expected inward current (hyperpolarization) to S cone isolating stimuli but also showed an outward current (depolarization) to L+M cone modulation. The spatial structure of the L+M cone surround is currently being investigated but preliminary data suggest a diam. circa 300 microns indicating that the S cone is both spatially and spectrally opponent and that the critical locus for S vs L+M cone opponency resides at the photoreceptor synapse.

Dacey, D. Packer, O. Verweij, J. Schnapf, J. (2007). Blue-Yellow opponent receptive field structure of primate S-cones [Abstract]. Journal of Vision, 7(15):5, 5a, http://journalofvision.org/7/15/5/, doi:10.1167/7.15.5. [CrossRef]
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×