December 2008
Volume 8, Issue 17
Free
Meeting Abstract  |   December 2008
Arrangement of the trichromatic cone mosaic in peripheral retina of a color-normal and a deutan Carrier
Author Affiliations
  • Osamu Masuda
    Center for Visual Science, University of Rochester, Rochester, NY, USA
  • Heidi Hofer
    College of Optometry, University of Houston, Houston, TX, USA
  • Joseph Carroll
    Department of Ophthalmology, The Medical College of Wisconsin, Milwaukee, WI, USA
  • David R. Williams
    Center for Visual Science, University of Rochester, Rochester, NY, USA
Journal of Vision December 2008, Vol.8, 9. doi:10.1167/8.17.9
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      Osamu Masuda, Heidi Hofer, Joseph Carroll, David R. Williams; Arrangement of the trichromatic cone mosaic in peripheral retina of a color-normal and a deutan Carrier. Journal of Vision 2008;8(17):9. doi: 10.1167/8.17.9.

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Purpose: Previous studies have concluded that the packing arrangement of foveal L and M cones is not distinguishable from random in most eyes. However, these measurements have been confined to retinal eccentricities of only about 1 deg from the foveal center. Here, we measured the packing arrangement in extrafoveal retina.

Methods: We classified the L, M, and S cones in a deutan carrier and a color-normal male subjects with adaptive optics imaging combined with retinal densitometry at 1.25, 4, and 10 deg in the temporal retina. We evaluated the packing arrangement of the 3 cone classes by comparing the frequencies of distances between all cones of the same type with those expected based on a random pigment assignment rule.

Results: Peripheral L and M cones of the deutan carrier exhibited significant clumping at 4 deg whereas those at 1.25 deg did not. The arrangement in the carrier at 10 deg had a tendency toward clumping but was not significant. The arrangement of the normal male was not significantly different from random both in the parafovea and in the periphery.

Conclusions: The organization of L and M cones outside the fovea, in a deutan carrier, shows a tendency toward clumping of cones of like type, as expected from X chromosome inactivation. This clumping may have implications for the strength of red-green color vision in peripheral retina since it increases the probability that peripheral midget cell centers will be driven by predominantly one class of cone.

Masuda, O. Hofer, H. Carroll, J. Williams, D. R. (2008). Arrangement of the trichromatic cone mosaic in peripheral retina of a color-normal and a deutan Carrier [Abstract]. Journal of Vision, 8(17):9, 9a, http://journalofvision.org/8/17/9/, doi:10.1167/8.17.9. [CrossRef]
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