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Changbing Huang, Jiawei Zhou, Zhong-Lin Lu, Lixia Feng, Yifeng Zhou; Binocular combination in anisometropic amblyopia. Journal of Vision 2009;9(8):297. doi: https://doi.org/10.1167/9.8.297.
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© ARVO (1962-2015); The Authors (2016-present)
Using a suprathreshold binocular summation paradigm developed by Ding and Sperling (2006, 2007) for normal observers, we investigated suprathreshold cyclopean perception in anisometropic amblyopia. In this paradigm, two suprathreshold sinewave gratings of the same spatial frequency but different spatial phases are presented to the left and right eyes of the observer. The perceived phase of the binocularly-combined cyclopean image is measured as a function of the contrast ratio between the two eyes. Contrast sensitivity functions were also measured. We found that both eyes contributed equally in normal subjects. However, stimulus of equal contrast was weighted much less in the amblyopic eye relative to the fellow eye in binocular combination. For the Five amblyopes, the effective contrast of the amblyopic eye in binocular combination is equal to about 11%–28% of the same contrast presented to the fellow eye, much less than the ratio of contrast sensitivity between the two eyes (0.73 – 1.42). A modified Ding-Sperling contrast-gain control model yielded very good accounts of all the data. The results from the current study have many important implications in amblyopia research and treatment.
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