August 2009
Volume 9, Issue 8
Free
Vision Sciences Society Annual Meeting Abstract  |   August 2009
Objective characterization of square-wave jerks differentiates progressive supranuclear palsy patients from healthy volunteers
Author Affiliations
  • Jorge Otero-Millan
    Barrow Neurological Institute, Phoenix, AZ, and University of Vigo, Spain
  • R. John Leigh
    Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH
  • Alessandro Serra
    Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH, and Institute of Clinical Neurology, University of Sassari, Italy
  • Xoana Troncoso
    Barrow Neurological Institute, Phoenix, AZ
  • Stephen L. Macknik
    Barrow Neurological Institute, Phoenix, AZ
  • Susana Martinez-Conde
    Barrow Neurological Institute, Phoenix, AZ
Journal of Vision August 2009, Vol.9, 370. doi:10.1167/9.8.370
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Jorge Otero-Millan, R. John Leigh, Alessandro Serra, Xoana Troncoso, Stephen L. Macknik, Susana Martinez-Conde; Objective characterization of square-wave jerks differentiates progressive supranuclear palsy patients from healthy volunteers. Journal of Vision 2009;9(8):370. doi: 10.1167/9.8.370.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

The eyes do not stay perfectly still during visual fixation. Fixational eye movements and saccadic intrusions continuously change the position of gaze. Here we focus on the most common type of saccadic intrusion: square-wave jerks (SWJs). SWJs are characterized by one small horizontal saccade that moves the eye away from the fixation target, followed by a corrective saccade towards the target shortly thereafter. SWJs are prevalent in some neurological diseases such as progressive supranuclear palsy (PSP). However, they are also common in normal subjects. We developed an objective algorithm to automatically identify SWJs in PSP patients and healthy volunteers, during visual fixation of a small target. Our results show that, whereas SWJs were common in both PSP patients and normals, SWJs in the PSP group had significantly higher rates and magnitudes, and were more markedly horizontal in direction. Using ROC (receiver operator characteristic) analyses we determined that the deviation from horizontal direction is the parameter that best distinguishes the PSP patient population from the population of healthy volunteers. The objective characterization of SWJs may provide a powerful tool in the differential diagnosis of oculomotor disease.

Otero-Millan, J. Leigh, R. J. Serra, A. Troncoso, X. Macknik, S. L. Martinez-Conde, S. (2009). Objective characterization of square-wave jerks differentiates progressive supranuclear palsy patients from healthy volunteers [Abstract]. Journal of Vision, 9(8):370, 370a, http://journalofvision.org/9/8/370/, doi:10.1167/9.8.370. [CrossRef]
Footnotes
 Supported by: the Barrow Neurological Foundation, the Arizona Biomedical Research Commission, NIH grant EY06717, the Office of Research and Development, Medical Research Service, Department of Veterans Affairs, the Evenor Armington Fund, and the OASI Institute for Research and Care (IRCCS) on Mental Retardation and Brain Aging, Troina, Italy.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×