May 2008
Volume 8, Issue 6
Free
Vision Sciences Society Annual Meeting Abstract  |   May 2008
Improving the signal-to-noise ratio of the visual P300
Author Affiliations
  • Sven P. Heinrich
    Universitäts-Augenklinik Freiburg
  • Dominik Mell
    Universitäts-Augenklinik Freiburg
  • Michael Bach
    Universitäts-Augenklinik Freiburg
Journal of Vision May 2008, Vol.8, 485. doi:10.1167/8.6.485
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      Sven P. Heinrich, Dominik Mell, Michael Bach; Improving the signal-to-noise ratio of the visual P300. Journal of Vision 2008;8(6):485. doi: 10.1167/8.6.485.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The P3b (“P300”) [1] of the event-related potential is considered to reflect cognitive —or even conscious [2]— stimulus processing. P300 recording sessions employ an “oddball paradigm”: target stimuli appear only infrequently among non-target stimuli. Thus they are quite lengthy and difficult to use with patients. We tested different strategies for minimizing the time needed to record a reliable visual P300. Targets were gratings of different orientation for target and non-target stimuli. Since previous studies only assessed absolute amplitude [e.g., 3, 4], we first determined the optimal signal-to-noise ratio for different target infrequencies. We found target-to-non-target ratios of 1:4 to 1:8 to be optimal. We next assessed whether shrinking the interval between stimulus onsets from 1000 ms to 214 ms would improve the signal-to-noise ratio when the recording time is kept constant, despite a temporal overlap of responses. This was indeed the case by a margin of up to 60%, but depended on the presentation duration of the stimuli. Finally, we assessed whether it is feasible to record a P300 in a manner similar to a steady-state visual evoked potential with a fixed number of intervening non-targets. We found a high inter-individual variability, but could reliably identify responses in all subjects with a multi-harmonic frequency-space analysis. Compared to conventional P300 recordings, less recording time was needed to acquire significant responses. In conclusion, the signal-to-noise ratio and the efficiency of visual P300 recordings can be improved by choosing optimal target infrequencies and by employing rapid stimulation schemes.

[1] Linden, D. E. J. (2005). Neuroscientist 11:563-576.

[2] Kotchoubey, B. (2005). Progr Brain Res 150:427-444.

[3] Johnson, Jr. R. (1986). Psychophysiology 23:367-384.

[4] Polich, J., & Margala, C. (1997). Int J Psychophysiol 25:169-176.

Heinrich, S. P. Mell, D. Bach, M. (2008). Improving the signal-to-noise ratio of the visual P300 [Abstract]. Journal of Vision, 8(6):485, 485a, http://journalofvision.org/8/6/485/, doi:10.1167/8.6.485. [CrossRef]
Footnotes
 Supported by the Deutsche Forschungsgemeinschaft (BA 877/18-1).
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