May 2008
Volume 8, Issue 6
Free
Vision Sciences Society Annual Meeting Abstract  |   May 2008
Objective characterization of square-wave jerks in progressive supranuclear palsy patients and healthy volunteers
Author Affiliations
  • Jorge Otero-Millan
    Barrow Neurological Institute, Phoeniz, AZ
  • R. John Leigh
    Veterans Affairs Med. Center, Case Western Reserve University, Cleveland, OH
  • Alessandro Serra
    Veterans Affairs Med. Center, Case Western Reserve University, Cleveland, OH, and Institute of Clinical Neurology, Sassari, Italy
  • Xoana Troncoso
    Barrow Neurological Institute, Phoeniz, AZ
  • Stephen Macknik
    Barrow Neurological Institute, Phoeniz, AZ
  • Susana Martinez-Conde
    Barrow Neurological Institute, Phoeniz, AZ
Journal of Vision May 2008, Vol.8, 931. doi:10.1167/8.6.931
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      Jorge Otero-Millan, R. John Leigh, Alessandro Serra, Xoana Troncoso, Stephen Macknik, Susana Martinez-Conde; Objective characterization of square-wave jerks in progressive supranuclear palsy patients and healthy volunteers. Journal of Vision 2008;8(6):931. doi: 10.1167/8.6.931.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The eyes do not stay perfectly still during visual fixation. Fixational eye movements and saccadic intrusions continuously change the position of the gaze. Here we focus on the most common type of saccadic intrusion: square-wave jerks (SWJs). SWJs are characterized by one small horizontal saccadic movement that moves the eye away from the fixation target, followed by a corrective saccade towards the target shortly thereafter. SWJs are prevalent in some neurological diseases such as progressive supranuclear palsy (PSP). However, they are also common in normal subjects. We developed an objective algorithm to automatically identify SWJs in PSP patients and normal subjects, during visual fixation of a small target. Our results show that SWJs are common in both PSP patients and normals. However, SWJ rates and magnitudes are larger in the PSP group. Thus the objective characterization of SWJs may provide a powerful new tool in the differential diagnosis of oculomotor disease.

Otero-Millan, J. Leigh, R. J. Serra, A. Troncoso, X. Macknik, S. Martinez-Conde, S. (2008). Objective characterization of square-wave jerks in progressive supranuclear palsy patients and healthy volunteers [Abstract]. Journal of Vision, 8(6):931, 931a, http://journalofvision.org/8/6/931/, doi:10.1167/8.6.931. [CrossRef]
Footnotes
 Supported by: the Barrow Neurological Foundation, the Arizona Biomedical Research Commission, NIH grant EY06717, the Office of Research and Development, Medical Research Service, Department of Veterans Affairs, the Evenor Armington Fund, and the OASI Institute for Research and Care (IRCCS) on Mental Retardation and Brain Aging, Troina, Italy.
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