August 2010
Volume 10, Issue 7
Free
Vision Sciences Society Annual Meeting Abstract  |   August 2010
Deficient Binocular Combination Reveals Mechanisms of Anisometropic Amblyopia
Author Affiliations
  • Chang-Bing Huang
    Laboratory of Brain Processes (LOBES), Department of Psychology, University of Southern California, Los Angeles, CA, USA
  • Jiawei Zhou
    School of Life Sciences, USTC, Hefei, Anhui, P.R. China
  • Yifeng Zhou
    School of Life Sciences, USTC, Hefei, Anhui, P.R. China
  • Zhong-Lin Lu
    Laboratory of Brain Processes (LOBES), Department of Psychology, University of Southern California, Los Angeles, CA, USA
Journal of Vision August 2010, Vol.10, 466. doi:10.1167/10.7.466
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Chang-Bing Huang, Jiawei Zhou, Yifeng Zhou, Zhong-Lin Lu; Deficient Binocular Combination Reveals Mechanisms of Anisometropic Amblyopia. Journal of Vision 2010;10(7):466. doi: 10.1167/10.7.466.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Amblyopia is a developmental visual disorder that results in poor spatial vision. Why the amblyopic eye has poor vision remains unclear: some suggested that signals in the amblyopic eye are attenuated; others suggested that they are inhibited by signals in the fellow eye. Huang et al. (2009) measured the perceived phase of the cyclopean image as a function of the contrast ratio between two monocular sinewave gratings of the same spatial frequency but different phases (Ding & Sperling, 2006). Although the study provided empirical measures of the relative strength of the amblyopic eye in binocular phase combination, we could not distinguish attenuation and inhibition models of amblyopia -- they make mathematically equivalent predictions on phase perception. Additional constrains are required. Here, we elaborated the Ding-Sperling paradigm, measuring both the perceived contrast and phase of the cyclopean images. We found that the effective contrast of the amblyopic eye is different in phase and contrast perception, and the perceived contrast of cyclopean images was independent of the relative phase of the monocular sinewave gratings. We developed a new binocular combination model in which each eye exerts gain control on the other eye's signal and over the other eye's gain control, followed by separate phase and contrast computations. The empirical data and computational model enabled us to identify the mechanism of amblyopia: signals in the amblyopic eye are attenuated; And, the amblyopic eye exerts weaker inhibition on the gain control from the fellow eye.

Huang, C.-B. Zhou, J. Zhou, Y. Lu, Z.-L. (2010). Deficient Binocular Combination Reveals Mechanisms of Anisometropic Amblyopia [Abstract]. Journal of Vision, 10(7):466, 466a, http://www.journalofvision.org/content/10/7/466, doi:10.1167/10.7.466. [CrossRef]
Footnotes
  Supported by NEI, Natural Science Foundation of China.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×