December 2010
Volume 10, Issue 15
Free
OSA Fall Vision Meeting Abstract  |   December 2010
Ultrahigh Speed Imaging with Swept Source Fourier Domain OCT
Author Affiliations
  • J. G. Fujimoto
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA
  • B. Potsaid
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA
    Thorlabs, Inc. Newton, NJ, USA
    New England Eye Center, Tufts-New England Medical Center, Boston, MA, USA
  • B. Baumann
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA
    Doheny Eye Center, University of Southern California, Los Angeles, CA, USA
  • J. Liu
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA
  • D. Huang
    Doheny Eye Center, University of Southern California, Los Angeles, CA, USA
  • J.S. Schuman
    UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  • J.S. Duker
    Thorlabs, Inc. Newton, NJ, USA
    New England Eye Center, Tufts-New England Medical Center, Boston, MA, USA
Journal of Vision December 2010, Vol.10, 12. doi:10.1167/10.15.12
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      J. G. Fujimoto, B. Potsaid, B. Baumann, J. Liu, D. Huang, J.S. Schuman, J.S. Duker; Ultrahigh Speed Imaging with Swept Source Fourier Domain OCT. Journal of Vision 2010;10(15):12. doi: 10.1167/10.15.12.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Swept source / Fourier domain OCT is a complementary technique to spectral / Fourier domain OCT which uses frequency swept lasers instead of a spectrometer and line scan camera. Swept source OCT enables imaging at 1050 nm wavelengths which improve sensitivity through ocular opacity as well as improve visualization of the choroid and optic nerve head. An ultrahigh speed, swept source prototype OCT system is demonstrated at axial scan rates of 200 kHz to 400 kHz (compared with 25 to 50 kHz for standard OCT instruments). The technology enables both wide field and high magnification OCT retinal imaging. 3D-OCT data sets of 6x6 mm of the retina, consisting of 700x700 axial scans can be acquired in <3 seconds. These data sets contain ∼500,000 axial scans, or ∼0.5 Gigavoxels of data, ∼10x more data than the standard Zeiss Cirrus cube. Large field of view OCT covering 12x12 mm, can be acquired with longer scan times. Using high magnifications and smaller fields of view, individual photoreceptors can be visualized. Images from dense volumetric data sets can be averaged to improve contrast and reduce noise. Longer wavelengths enable deeper penetration into the choroid and optic nerve head. The ultrahigh imaging speeds provided by swept source OCT enable new imaging protocols which can cover large retinal areas with standard resolutions, or small retinal areas with high resolution. These advantages suggest that swept source OCT will be an important technology for the next generation of ophthalmic OCT instruments.

Acknowledgments
Supported in part by NIH R01-EY11289-24, R01-EY013178-10, R01-EY013516-06, AFOSR FA9550-07-1-0101 and FA9550-07-1-0014. 
Financial Disclosure. JGF and JSS receive royalties from intellectual property licensed by MIT to Carl Zeiss Meditec. JGF and DH have stock options in Optovue. 
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