December 2010
Volume 10, Issue 15
Free
OSA Fall Vision Meeting Abstract  |   December 2010
Effect of ocular aberration on visual acuity and contrast sensitivity after penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), and Descemet's stripping automated endothelial keratoplasty (DSAEK)
Author Affiliations
  • Seth M. Pantanelli
    Flaum Eye Institute, University of Rochester, Rochester, NY, USA
  • Ramkumar Sabesan
    Center for Visual Science, University of Rochester, Rochester, NY, USA
  • Xaowei Cai
    Flaum Eye Institute, University of Rochester, Rochester, NY, USA
  • Steven Ching
    Flaum Eye Institute, University of Rochester, Rochester, NY, USA
  • Geuyoung Yoon
    Flaum Eye Institute, University of Rochester, Rochester, NY, USA
  • Holly B. Hindman
    Flaum Eye Institute, University of Rochester, Rochester, NY, USA
Journal of Vision December 2010, Vol.10, 76. doi:10.1167/10.15.76
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      Seth M. Pantanelli, Ramkumar Sabesan, Xaowei Cai, Steven Ching, Geuyoung Yoon, Holly B. Hindman; Effect of ocular aberration on visual acuity and contrast sensitivity after penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), and Descemet's stripping automated endothelial keratoplasty (DSAEK). Journal of Vision 2010;10(15):76. doi: 10.1167/10.15.76.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To study the role of higher-order aberrations (HOAs) in impairment of best-corrected visual acuity (VA) and contrast sensitivity (CS) following PK, DALK and DSAEK surgeries.

Methods: Eyes were evaluated 3 months (PK, n=2; DALK, n=1; DSAEK, n=2) and greater than 1 year (PK, n=4; DALK, n=5; DSAEK, n=3) post-keratoplasty. An adaptive optics (AO) system was used to non-invasively correct the HOAs; VA and CS was then measured without and with AO.

Results: Without AO, PK eyes had 1.05 ± 0.79 and 1.07 ± 0.43, DALK had 1.02 and 0.69 ± 0.24, and DSAEK eyes had 0.67 ± 0.36 and 0.65 ± 0.43 μm of root mean square HOA at 3 months and 1 year post-op, respectively. At 3 months, without and with AO correction, PK eyes achieved logMAR VAs of 0.32 ± 0.13 and 0.08 ± 0.10, DALK VAs of 0.09 and 0, and DSAEK VAs of 0.36 ± 0.12 and 0.25 ± 0.06. At one year these acuities improved to 0.02 ± 0.12 and -0.12 ± 0.15 for PK, 0.11 ± 0.18 and -0.05 ± 0.18 for DALK, and 0.24 ± 0.15 and 0.01 ± 0.10 for DSAEK. All post-op groups benefited equally with regards to CS when aberrations were corrected with AO.

Conclusions: Despite having less HOA than PK eyes and the same amount as DALK eyes, DSAEK subjects tended toward poorer performance on VA testing, and did not achieve similar acuities as PK and DALK subjects when aberrations were corrected with AO. This suggests that other factors, such as scatter, may be playing a proportionately larger role in limiting visual performance in DSAEK.

Acknowledgments
Grants: 
- NIH 1K23EY019353-01, 3K23EY019353-01S1, 5R01EY014999 
- NYSTAR/CEIS 
- RPB (Research to Prevent Blindness) 
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