December 2011
Volume 11, Issue 15
Free
OSA Fall Vision Meeting Abstract  |   December 2011
Aging and dementia in human visual cortex: Visual field map organization and population receptive fields
Author Affiliations
  • Alyssa Brewer
    University of California, Irvine, Cognitive Sciences
  • Brian Barton
    University of California, Irvine, Cognitive Sciences
Journal of Vision December 2011, Vol.11, 28. doi:10.1167/11.15.28
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      Alyssa Brewer, Brian Barton; Aging and dementia in human visual cortex: Visual field map organization and population receptive fields. Journal of Vision 2011;11(15):28. doi: 10.1167/11.15.28.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Aging typically results in reduced visual acuity, both from changes within the eye and from acquired neural deficits. It is not known, however, to what extent aging affects visual field map organization in human cortex. In addition, patients with Alzheimer's disease (AD) often present with visual deficits as one of their earliest complaints. It is possible that measurements of changes in visual cortex in these patients could aid early detection, accurate diagnosis and timely treatment of dementia. Here we investigate the differences and similarities of visual fields map organization and population receptive fields (pRFs) between patients with mild-to-moderate AD and healthy age-matched controls. We measured visual field map organization and pRFs across visual cortex using fMRI in healthy young volunteers ages 20–40, normally-aging subjects ages 55–85, and age-matched patients with mild-to-moderate AD. Retinotopic stimuli consisted of black and white, drifting checkerboards 11° in radius comprising wedges, rings, and/or bars. Normally-aging subjects do not show major visual field map organizational deficits, but do have increased pRF sizes in the central foveal representations of occipital and parietal visual field maps. AD patients do show visual field map organizational deficits and increases in pRFs increase in size and variability relative to age-matched controls.

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