December 2002
Volume 2, Issue 10
Free
OSA Fall Vision Meeting Abstract  |   December 2002
Sweep visual evoked potentials in infants with infantile spasms before and during vigabatrin treatment
Author Affiliations
  • Sharon E. Morong
    Department of Ophthalmology, Hospital for Sick Children, Toronto, Ontario, Canada
  • Carol A. Westall
    Ophthalmology, Hospital for Sick Children and University of Toronto, Toronto, Canada
  • J. Raymond Buncic
    Ophthalmology, Hospital for Sick Children and University of Toronto, Toronto, Canada
  • O. Carter Snead
    Neurology, Hospital for Sick Children and University of Toronto, Toronto, Canada
  • William Logan
    Neurology, Hospital for Sick Children and University of Toronto, Toronto, Canada
  • Shelly Weiss
    Neurology, Hospital for Sick Children and University of Toronto, Toronto, Canada
Journal of Vision December 2002, Vol.2, 93. doi:10.1167/2.10.93
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      Sharon E. Morong, Carol A. Westall, J. Raymond Buncic, O. Carter Snead, William Logan, Shelly Weiss; Sweep visual evoked potentials in infants with infantile spasms before and during vigabatrin treatment. Journal of Vision 2002;2(10):93. doi: 10.1167/2.10.93.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose To investigate the effect of vigabatrin on contrast sensitivity and visual acuity in infants with Infantile Spasms (IS).

Methods Sweep visual evoked potentials were used to assess contrast sensitivity and visual acuity in infants (8mos – 2.1 yrs, median 9.5 mos) with IS pre-vigabatrin (baseline). These results were compared with historical sweep VEP data of children (1.3yrs – 1.5yrs, median 1.45 yrs) with normal vision. Baseline results were also compared with historical data of age-similar children on vigabatrin: (1) showing NO signs of toxicity and (2) showing signs of toxicity (as determined by fundus examination and ERG).

Preliminary Results A two-tailed t-test showed that infants (n=9) with IS had a significant peak contrast sensitivity deficit (p<0.02) and a significant visual acuity deficit (p<0.01) before starting vigabatrin compared with infants with normal vision. A slight reduction in peak contrast sensitivity is seen in children showing signs of toxicity, when compared to baseline results.

Discussion Infants with IS have significant visual deficits in contrast sensitivity and visual acuity. Longitudinal follow up will determine the effect of vigabatrin on visual functions

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Norcia,A.M.,& Tyler,C.W.(1985).Spatial frequency sweep VEP: visual acuity during the first year of life. Vision Res. 25(10),1399–1408.

Sabers,A., & Lennart,G.(1992). Pharmacology of Vigabatrin. Pharmacology & Toxicology 70,237–243.

Nousiainen,I.,Kalviainen,R.,Mantyjarvi,M.(2000) Contrast & Glare sensitivity in epilepsy patients treated with Vigabatrin or Carbamazepine monotherapy compared with healthy volunteers. Br. J. Ophthalmology 84(6),622–625.

Morong, S. E., Westall, C. A., Buncic, R., Snead, O. C.III, Logan, W., Weiss, S.(2002). Sweep visual evoked potentials in infants with infantile spasms before and during vigabatrin treatment [Abstract]. Journal of Vision, 2( 10): 93, 93a, http://journalofvision.org/2/10/93/, doi:10.1167/2.10.93. [CrossRef]
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