December 2002
Volume 2, Issue 10
Free
OSA Fall Vision Meeting Abstract  |   December 2002
Localized functional age-related changes in the central retina assessed by multifocal ERG
Author Affiliations
  • Radouil Tzekov
    UC Davis, Sacramento, CA, USA
  • Christina Gerth
    Department of Ophthalmology, UC Davis, Sacramento, USA
  • John S. Werner
    Ophthalmology, and Neurobiology, Physiology & Behavior, UC-Davis, Sacramento, CA, USA
Journal of Vision December 2002, Vol.2, 97. doi:10.1167/2.10.97
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      Radouil Tzekov, Christina Gerth, John S. Werner; Localized functional age-related changes in the central retina assessed by multifocal ERG. Journal of Vision 2002;2(10):97. doi: 10.1167/2.10.97.

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Abstract
 

Introduction: Previous studies have shown significant age-related change in the first-order kernel response of the multifocal ERG (mfERG). However, they all involved use of ring averages across the retinal field. Purpose: To estimate the age-related changes in the localized response and retinal topography using point-to-point comparison. To determine the localized variability in the mfERG scalar product across age and the topography of the age-related change. Methods: MfERG recordings of 71 normal phakic subjects (ages 9–80) were analyzed with VERIS TM 4.8. The stimulus parameters were: 103 hexagons, 75 Hz frame rate, peak luminance 200 cd/m2, m= 2^14. Scalar products (for each hexagon based on ring average templates) were obtained and analyzed for age-related changes. Statistical measures (coefficient of variation (CV) and parameters of a linear regression model) were applied. Point-by-point comparison for hemifields was performed. Results: Each localized response showed a significant aging effect. The average decline of the response for all hexagons was t} 5%/decade varying from 3.3% (peripherally) to 7.5% (perifoveally). The average CV for all subjects at all locations was 29.4% (± 4.1%). The CV distribution was relatively homogenous across the retina except for a small region around the optic disc (4 hexagons), which was excluded from further analysis. Topographical maps of the parameters of the linear regression model showed a distribution that was different from the topography of the ring averages. The rate of change was significantly higher for the superior then for the inferior retina, but no naso-temporal asymmetry with age was found. Conclusions: Our data for CV are consistent with the data previously reported for samples with a more restricted age range. Information about change of individual hexagons with age should make the mfERG more useful in quantitatively monitoring progression of retinal disease.

 
Tzekov, R., Gerth, C., Werner, J. S.(2002). Localized functional age-related changes in the central retina assessed by multifocal ERG [Abstract]. Journal of Vision, 2( 10): 97, 97a, http://journalofvision.org/2/10/97/, doi:10.1167/2.10.97. [CrossRef]
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