September 2015
Volume 15, Issue 12
Free
Vision Sciences Society Annual Meeting Abstract  |   September 2015
Saliency-guided eye movement during free-viewing in schizophrenic patients
Author Affiliations
  • Masatoshi Yoshida
    Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Japan School of Life Science, The Graduate University for Advanced Studies, Hayama, Japan
  • Kenichiro Miura
    Department of Integrative Brain Science, Graduate School of Medicine, Kyoto University, Japan
  • Ryota Hashimoto
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan
  • Michiko Fujimoto
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
  • Hidenaga Yamamori
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
  • Yuka Yasuda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
  • Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
  • Masaki Fukunaga
    Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Aichi, Japan
  • Masatoshi Takeda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
  • Tadashi Isa
    Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Japan School of Life Science, The Graduate University for Advanced Studies, Hayama, Japan
Journal of Vision September 2015, Vol.15, 61. doi:10.1167/15.12.61
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    • Get Citation

      Masatoshi Yoshida, Kenichiro Miura, Ryota Hashimoto, Michiko Fujimoto, Hidenaga Yamamori, Yuka Yasuda, Kazutaka Ohi, Masaki Fukunaga, Masatoshi Takeda, Tadashi Isa; Saliency-guided eye movement during free-viewing in schizophrenic patients. Journal of Vision 2015;15(12):61. doi: 10.1167/15.12.61.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Patients with schizophrenia show various kinds of abnormality in eye movements. Recent studies showed that such abnormalities, including the shorter scanpath during free-viewing of natural images, is able to use as an efficient biomarker for schizophrenia. Here we extended our previous work (Miura et.al. 2014 Schizophr Res) and examined whether such difference in eye movements during free-viewing arises from the way in which their attention is drawn to specific features of the visual stimuli. The age-matched subjects (41 patients and 72 healthy controls) viewed 56 natural and/or complex images including faces, scenes and so on. During 8 seconds of viewing time for each image, eye movements were recorded using an eye tracker (EyeLink 1000). We calculated the saliency map of the images for low-level features (luminance, L-M, S-Lum and orientation) based on our previous work (Yoshida et.al. 2012 Curr. Biol.). Then we evaluated the time course of the saliency value at the position of the gaze. The luminance saliency was highest for the first fixation and went down during the 8-sec viewing time in the healthy controls. This is also true for patient group but the luminance saliency was consistently higher in the patients than in the healthy controls (repeated measures ANOVA, F1,111=5.78, P=0.017). The saliency for other features showed different time course. By combining saliency values for different features (4 models * 8 time points), we constructed a classifier in which patients and controls are distinguished with 83% accuracy. These results suggest that the abnormality in eye movements during visual exploration can be explained, at least partly, by dysregulated saliency in the patients.

Meeting abstract presented at VSS 2015

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