September 2015
Volume 15, Issue 12
Free
Vision Sciences Society Annual Meeting Abstract  |   September 2015
Illusory Motion Perception Is Impaired in individuals with DCDC2 Intron 2 Deletion showing the Selective Role of Magnocellular-Dorsal Stream in Dyslexia
Author Affiliations
  • Sara Mascheretti
    Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy,
  • Simone Gori
    Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy, Developmental and Cognitive Neuroscience Lab, Department of General Psychology, University of Padua, 35131 Padua, Italy,
  • Enrico Giora
    Faculty of Psychology,"Vita-Salute" San Raffaele University, 20132 Milan, Italy,
  • Luca Ronconi
    Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy, Developmental and Cognitive Neuroscience Lab, Department of General Psychology, University of Padua, 35131 Padua, Italy,
  • Milena Ruffino
    Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy,
  • Ermanno Quadrelli
    Department of Psychology, University of Milan-Bicocca, 20126 Milan, Italy,
  • Andrea Facoetti
    Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy, Developmental and Cognitive Neuroscience Lab, Department of General Psychology, University of Padua, 35131 Padua, Italy,
  • Cecilia Marino
    Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy, Centre de Recherche de L'Institut Universitaire en Santé Mentale de Québec, Québec, QC, Canada G1J 2G3
Journal of Vision September 2015, Vol.15, 481. doi:10.1167/15.12.481
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      Sara Mascheretti, Simone Gori, Enrico Giora, Luca Ronconi, Milena Ruffino, Ermanno Quadrelli, Andrea Facoetti, Cecilia Marino; Illusory Motion Perception Is Impaired in individuals with DCDC2 Intron 2 Deletion showing the Selective Role of Magnocellular-Dorsal Stream in Dyslexia. Journal of Vision 2015;15(12):481. doi: 10.1167/15.12.481.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Developmental dyslexia (DD) is a heritable neurodevelopmental reading disorder that seems to arise from auditory, visual, and cross-modal integration deficits. A deletion in intron 2 of the DCDC2 gene (hereafter DCDC2d) increases the risk for DD. First, we show that illusory visual motion perception-specifically processed by the magnocellular-dorsal (M-D) stream- is impaired in children with DD compared with age-matched and reading-level controls. Second, we test for the specificity of the DCDC2d effects on the M-D stream. Children with DD and DCDC2d need significantly more contrast to process illusory motion in comparison to their counterpart without DCDC2d and to age-matched and reading-level controls. Regardless the genetic variant, children with DD perform typically in the parvocellular-ventral task. Finally, DCDC2d influenced illusory motion perception also in adult typical readers, showing that the M-D deficit is a potential neurobiological risk factor of DD rather than an effect of reading disorder. Our findings demonstrate, for the first time, that a specific neurocognitive dysfunction tapping the M-D stream is associated with a well-defined genetic susceptibility.

Meeting abstract presented at VSS 2015

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