September 2015
Volume 15, Issue 12
Free
Vision Sciences Society Annual Meeting Abstract  |   September 2015
Normal repetition probability effects in the occipito-temporal cortex in Schizophrenia
Author Affiliations
  • Mareike Grotheer
    Department of Cognitive Neuroscience, Institute of Psychology, Friedrich Schiller University Jena, 07743 Jena, Germany DFG Research Unit Person Perception, Friedrich Schiller University Jena, 07743 Jena, Germany
  • Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, 07743 Jena, Germany
  • Lisa Münke
    Department of Psychiatry and Psychotherapy, Jena University Hospital, 07743 Jena, Germany
  • Szabolcs Kéri
    Department of Cognitive Science, Budapest University of Technology and Economics, 1111 Budapest, Hungary
  • Gyula Kovács
    Department of Cognitive Neuroscience, Institute of Psychology, Friedrich Schiller University Jena, 07743 Jena, Germany DFG Research Unit Person Perception, Friedrich Schiller University Jena, 07743 Jena, Germany
Journal of Vision September 2015, Vol.15, 1193. doi:10.1167/15.12.1193
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      Mareike Grotheer, Igor Nenadic, Lisa Münke, Szabolcs Kéri, Gyula Kovács; Normal repetition probability effects in the occipito-temporal cortex in Schizophrenia. Journal of Vision 2015;15(12):1193. doi: 10.1167/15.12.1193.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A growing body of evidences suggests that the comparison of expected and incoming sensory stimuli (predictive error (PE) processing) is impaired in schizophrenia (SZ). For example in studies of mismatch negativity, an ERP component that signals PE, SZ patients show deficits in both the auditory (Fulham et al., 2014) and the visual (Neuhaus, Brandt, Goldberg, Bates, & Malhotra, 2013) modality. In order to test the role of impaired PE processing in SZ further, using neuroimaging methods, we applied a repetition suppression (RS) paradigm (Summerfield, Trittschuh, Monti, Mesulam, & Egner, 2008). 17 patients diagnosed with SZ according to DSM-IV-R / DSM V as well as 17 age and gender matched healthy control (HC) subjects were presented with pairs of faces which could either repeat or alternate. Additionally, the likelihood of repetition/alternation trials was modulated in individual blocks of fMRI recordings, testing the effects of repetition probability (P(rep)) on RS. We found a significant RS in the fusiform and occipital face areas, as well as in the lateral occipital cortex that was similar in both groups. More importantly, we observed similar P(rep) effects (significant RS in blocks with high repetition likelihood but not in blocks with low repetition likelihood) in both groups as well. Crucially, this suggests normal predictive processes in patients with Schizophrenia.

Meeting abstract presented at VSS 2015

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