August 2016
Volume 16, Issue 12
Open Access
Vision Sciences Society Annual Meeting Abstract  |   September 2016
Retinal activity guides visual circuit development prior to sensory experience
Author Affiliations
  • Michael C. Crair
    Yale
Journal of Vision September 2016, Vol.16, 927. doi:10.1167/16.12.927
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      Michael C. Crair; Retinal activity guides visual circuit development prior to sensory experience. Journal of Vision 2016;16(12):927. doi: 10.1167/16.12.927.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Classic models emphasize an important role of sensory experience in the development of visual circuits in the mammalian brain. However, recent evidence indicates that fundamental features of visual circuits in the thalamus, cortex and superior colliculus emerge prior to the emergence of form vision. I will summarize our latest experiments that use in vivo optical imaging techniques and molecular-genetic manipulations in mice to demonstrate that spontaneous retinal activity, generated prior to vision, plays an essential role in sculpting the development of visual circuits in the mammalian brain.

Meeting abstract presented at VSS 2016

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