June 2017
Volume 17, Issue 7
Open Access
OSA Fall Vision Meeting Abstract  |   June 2017
Can training in the subacute post-stroke period generate greater visual recovery after V1 damage?
Journal of Vision June 2017, Vol.17, 15. doi:10.1167/17.7.15
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      Elizabeth L. Saionz, Bogachan Sahin, Zoe Williams, Krystel R. Huxlin; Can training in the subacute post-stroke period generate greater visual recovery after V1 damage?. Journal of Vision 2017;17(7):15. doi: 10.1167/17.7.15.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Stroke damage to V1 in adult humans causes cortical blindness (CB). Visual training in chronic (>6 months) stroke patients decreases the deficit but recovered vision is subnormal (1,2). In motor stroke, earlier rehabilitation leads to greater recovery (3). Here, we asked if visual training initiated soon after stroke leads to better improvement in CB. Subacute (<3 months) stroke patients were trained to discriminate global direction of random dot stimuli. Initially, blind field performance was at chance. After daily home training for 3 months, CBs attained intact-level motion integration thresholds at all trained blind field locations. Unlike chronic CBs, subacute CBs exhibited transfer of recovery to untrained locations up to 10 deg deeper into the blind field. CBs who began training <2 months post-stroke also demonstrated improved performance on an untrained fine direction discrimination task. Thus, training initiated in subacute CB generates faster, more generalized visual improvements than in chronic CB.

Meeting abstract presented at the 2016 OSA Fall Vision Meeting

Huxlin, KR, Martin, T, Kelly, K Perceptual Relearning of Complex Visual Motion after V1 Damage in Humans 2009. doi:10.1523/JNEUROSCI.4882-08.2009
Das, A, Tadin, D, Huxlin, KR.Beyond Blindsight: Properties of Visual Relearning in Cortically Blind Fields J Neurosci. 2014. 34(35): 11652–11664 doi:10.1523/JNEUROSCI.1076-14.2014 [CrossRef] [PubMed]
Duncan, PW, Zorowitz, R, Bates, B Management of Adult Stroke Rehabilitation Care: a clinical practice guideline Stroke 2005. 36(9): e100–e143 doi:10.1161/01.STR.0000180861.54180.FF [CrossRef] [PubMed]
Footnotes
 This work was supported by NIH R01 EY021209 (KRH), NIH P30 EY001319 (UR-CVS), Schmitt Program on Integrative Brain Research (KRH), Research to Prevent Blindness Foundation (UR-FEI), Medical Scientist Training Program NIH T32GM007356 and institutional funds(ELS).
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