September 2017
Volume 17, Issue 10
Open Access
Vision Sciences Society Annual Meeting Abstract  |   August 2017
Comparative neuroanatomy of occipital white matter tracts in human and macaque
Author Affiliations
  • Hiromasa Takemura
    Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, and Osaka University
    Graduate School of Frontier Biosciences, Osaka University
  • Franco Pestilli
    Department of Psychological and Brain Sciences, Indiana University
  • Kevin Weiner
    Department of Psychology, Stanford University
  • Georgios Keliris
    Max Planck Institute for Biological Cybernetics
    Bio-Imaging Lab, Department of Biomedical Sciences, University of Antwerp
  • Sofia Landi
    The Rockefeller University
  • Julia Sliwa
    The Rockefeller University
  • Frank Ye
    Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Eye Institute, National Institutes of Health
  • Michael Barnett
    Department of Psychology, Stanford University
  • David Leopold
    Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Eye Institute, National Institutes of Health
  • Winrich Freiwald
    The Rockefeller University
  • Nikos Logothetis
    Max Planck Institute for Biological Cybernetics
  • Brian Wandell
    Department of Psychology, Stanford University
Journal of Vision August 2017, Vol.17, 589. doi:10.1167/17.10.589
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      Hiromasa Takemura, Franco Pestilli, Kevin Weiner, Georgios Keliris, Sofia Landi, Julia Sliwa, Frank Ye, Michael Barnett, David Leopold, Winrich Freiwald, Nikos Logothetis, Brian Wandell; Comparative neuroanatomy of occipital white matter tracts in human and macaque. Journal of Vision 2017;17(10):589. doi: 10.1167/17.10.589.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The macaque monkey has been an important model for understanding human vision. A substantial literature compares human and macaque functional cortical responses to visual stimuli in order to better understand cellular mechanisms from macaque studies (Tootell et al. 2003; Wandell and Winawer 2011; Vanduffel et al. 2014). The anatomical connections in the white matter are another important source for clarifying the similarities and differences between human and macaque cortex. Recent progress on diffusion MRI and tractography enables us to identify major white matter pathways from human brains (Catani et al. 2002; Schmahmann et al. 2007; Wandell 2016). This study compares the organization of major occipital white matter tracts in human and macaque. We analyzed diffusion MRI data, collected from 4 macaques and 10 humans using the Ensemble Tractography method (Takemura et al., 2016). We identified several apparently homologous tracts in the two species, including the vertical occipital fasciculus (VOF), optic radiation, forceps major, and inferior longitudinal fasciculus (ILF). There is one large human tract, the inferior fronto-occipital fasciculus, with no corresponding fasciculus in macaque. Then we focused on the macaque VOF, which has been little studied (Yeatman et al., 2014). The estimated macaque VOF position is consistent with classical invasive anatomical studies by Wernicke. The homology of human and macaque VOF is supported because the endpoints are near similar maps (V3A and ventral V4) between human and macaque. However, the macaque VOF fibers intertwine with the dorsal segment of the ILF, while the human VOF are relatively lateral to the ILF. These similarities and differences will be useful in establishing which circuitry in the macaque can serve as an accurate model for human visual cortex.

Meeting abstract presented at VSS 2017

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