September 2017
Volume 17, Issue 10
Open Access
Vision Sciences Society Annual Meeting Abstract  |   August 2017
Changes in functional activation for audiovisual stimuli in people with one eye
Author Affiliations
  • Stefania Moro
    Department of Psychology, York University, Toronto, Canada
    Centre for Vision Research, York University, Toronto, Canada
  • Sara Rafique
    Department of Psychology, York University, Toronto, Canada
    Centre for Vision Research, York University, Toronto, Canada
  • Ben Shachar
    Department of Biology, York University, Toronto, Canada
  • Brenda Gallie
    Department of Ophthalmology and Visual Sciences, The Hospital for Sick Children, Toronto, Canada
  • Jennifer Steeves
    Department of Psychology, York University, Toronto, Canada
    Centre for Vision Research, York University, Toronto, Canada
Journal of Vision August 2017, Vol.17, 1355. doi:10.1167/17.10.1355
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      Stefania Moro, Sara Rafique, Ben Shachar, Brenda Gallie, Jennifer Steeves; Changes in functional activation for audiovisual stimuli in people with one eye. Journal of Vision 2017;17(10):1355. doi: 10.1167/17.10.1355.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

People who have lost one eye early in life have enhanced sound localization (Hoover et al., 2011), lack visual dominance (Moro & Steeves, 2011) and integrate auditory and visual information optimally (Moro et al., 2013) compared with binocular and eye-patched viewing controls. Structurally, people with one eye have a less severe decrease in volume of the lateral geniculate nucleus contralateral to the remaining eye (Kelly et al., 2013). In addition, they have an asymmetry in medial geniculate body volume, larger in the left hemisphere compared to right, independent of which eye is removed (Moro et al., 2015). Given the existing audiovisual processing differences and structural changes in people with one eye, we investigated whether changes in functional activation for audiovisual stimuli are also present. Functional images were acquired with a 3T MRI scanner while participants were asked to observe a video of a speaker reading a story in an auditory only, visual only or audiovisual condition. A whole brain analysis to measure brain activity for auditory, visual and audiovisual stimuli was conducted in adults who had undergone early unilateral eye enucleation (surgical removal of one eye) compared to binocularly intact and eye-patched controls. People with one eye demonstrated increased activation in the auditory cortex contralateral to their removed eye for auditory stimuli and increased activation in the auditory, occipital and frontal cortex for audiovisual stimuli compared with controls. People with one eye demonstrated decreased activation in the occipital cortex contralateral to their removed eye for visual stimuli. In addition, they showed increased activation in the bilateral cuneus and fusiform gyrus ipsilateral to their removed eye for visual stimuli compared with controls. These functional changes, combined with changes in underlying neural structure provide evidence for compensatory reorganization for the loss of one half of visual inputs early in life.

Meeting abstract presented at VSS 2017

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