December 2017
Volume 17, Issue 15
Open Access
OSA Fall Vision Meeting Abstract  |   December 2017
Measuring melanopsin function in people
Author Affiliations
  • Manuel Spitschan
    University of Oxford
Journal of Vision December 2017, Vol.17, 2. doi:10.1167/17.15.2
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Manuel Spitschan; Measuring melanopsin function in people. Journal of Vision 2017;17(15):2. doi: 10.1167/17.15.2.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

The spectral, spatial and temporal properties of the retinal mechanisms underlying circadian phase shifting and melatonin suppression by bright light are an important area of investigation. Practical applications include the design of lighting solutions to minimize adverse effects of light at night, and optimizing lighting schedules to address circadian desynchronization due to shift work and jet lag. The photopigment melanopsin, expressed in a subset of retinal ganglion cells, rendering them intrinsically photosensitive, is thought to largely mediate these “non-image-forming” effects of light. Using the method of silent substitution, which allows for the targeted stimulation of melanopsin in humans, we have made progress in measuring and understanding the contributions of melanopsin to the pupillary light reflex and to primary visual cortex. A key focus has been on developing methods to assess the quality of isolation of melanopsin with minimal inadvertent stimulation of the cones. Future work using the silent substitution paradigm will tease apart the different photoreceptor contributions to the human circadian system.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×