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Stacey S. Choi, Robert J. Zawadzki, John S. Werner; High-resolution imaging of retinal disease and their retinal function. Journal of Vision 2006;6(13):37. doi: 10.1167/6.13.37.
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Patients with variety of retinal diseases were evaluated with high-resolution imaging instruments constructed at UC Davis and by testing retinal functions. Functional tests included multifocal electroretinogram (mfERG), color vision, visual fields and contrast sensitivity using stimuli presented at the locations corresponding to retinal imaging. The imaging instruments included: (1) adaptive optics (AO) flood-illumination which results in approximately 2 µm lateral resolution, (2) Fourier-domain optical coherence tomography (Fd-OCT) providing high speed (9–36 frames/sec) B-scans with either ∼3, 4.5 or 6 µm axial resolution and 15 µm lateral resolution and (3) AO - Fd-OCT which has both high-lateral (3.5 µm) and high-axial (6 µm) resolution. Both AO instruments revealed changes in the cone photoreceptors, which correlated with localized functional changes. Due to the high speed of Fd-OCT, it is possible to acquire volumetric data of retinal structures. The 3D reconstruction of retina revealed structures that have not been visualized with commercial instruments.
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