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Sandra E. Leh, M. Mallar Chakravarty, Alain Ptito; The connectivity of the human pulvinar: a diffusion tensor imaging tractography study. Journal of Vision 2007;7(9):224. doi: 10.1167/7.9.224.
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Introduction: Previous studies in nonhuman primates and cats have shown that the pulvinar receives input from various cortical and subcortical areas involved in vision. Although the contribution of the pulvinar to human vision remains to be established, anatomical tracer and electrophysiological animal studies on cortico-pulvinar circuits suggest an important role of this structure to visual spatial attention, visual integration (e.g. 1) and higher-order visual processing (2, 3). Because methodological constraints limit human investigations of the pulvinar's function, its role can at present only be deduced from animal studies (e.g. 4, 5). Methods: In the present study, we used an innovative imaging technique namely, Diffusion Tensor Imaging (DTI) tractography, to determine cortical and subcortical connections of the human pulvinar. We were able to reconstruct pulvinar fiber tracts and compare variability across subjects in vivo. Results: Here we demonstrate that the human pulvinar is interconnected with subcortical structures (superior colliculus, thalamus and caudate nucleus) as well as with cortical structures (primary visual areas (area 17), secondary visual areas (area 18, 19), visual inferotemporal areas (area 20), posterior parietal association areas (area 7), frontal eye fields and prefrontal areas). These results are consistent with the connectivity reported in animal anatomical studies (e.g. 1, 6, 7, 8, 9). References: (1) Casanova, Freeman & Nordmann, 1989; (2) Casanova et al., 2001; (3) Villeneuve et al., 2005 (2) Shipp, 2004; (5) Grieve, Acuna & Cudeiro, 2000; (6) Hutsler & Chalupa, 1991; (7) Chalupa, Anchel & Lindsley, 1972; (8) Yeterian & Pandya, 1985; (9) Shipp, 2001.
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