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Ahmad Reza, Ali Abdollahi, Hassan Attarchi, Mehrnaz Ghasemi Esfe; Central Corneal Thickness and Medically Uncontrolled primary open angel glaucoma. Journal of Vision 2007;7(15):66. doi: 10.1167/7.15.66.
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purpose: Current evidences have determined clearly the role of central corneal thickness (CCT) in progression and development of Primary Open-Angle Glaucoma, but its effect on the level of glaucoma severity remains uncertain. This study was designed to expand the available knowledge about the relationship between central corneal thickness and glaucoma severity with comparing two medically controlled and medically uncontrolled glaucoma groups. Patients and Methods: Patients with past diagnosis of open-angle glaucoma, who were seen at glaucoma clinic of Farabi Hospital, participated in this retrospective case control study. Patients in Case group were those with primary open-angle glaucoma that intra ocular pressure(IOP) reduction of their affected eyes with maximum dose of medications has not been sufficient and because of visual field loss with or without increased in cup-to-disc ratio, they had been got elected for trabeculectomy. Control group was containing patients with primary open-angle glaucoma whom their disease has been under control with medical treatment and they were not considered for glaucoma filtering surgery. Results: Intra ocular pressure, Visual Acuity, Cup-to-Disc Ratio, and Number of Medication had significant association with medically uncontrolled glaucoma. The mean central corneal thickness in case subjects was 547.4 µm and in controls was 544.4 µm (P = 0.71). In comparison between two groups, these variables had no meaningful relationship: Age, Gender, central corneal thickness, Family history, Smoking, Hypertension, Diabetes and Visual Field. Conclusions: In this study, central corneal thickness had no meaningful association with medically uncontrolled open angle glaucoma. It seems, like some recent evidences central corneal thickness could not predict the level of glaucoma severity and this is contrary to well recognized ability of central corneal thickness to predict development of primary open-angle glaucoma. I want to be considered for the OSA Young Investigator Award
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