December 2009
Volume 9, Issue 14
OSA Fall Vision Meeting Abstract  |   December 2009
The role of arrestin In melanopsin function
Author Affiliations
  • Megumi Hatori
    The Salk Institute for Biological Studies
  • Satchin Panda
    The Salk Institute for Biological Studies
Journal of Vision December 2009, Vol.9, 41. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Megumi Hatori, Satchin Panda; The role of arrestin In melanopsin function. Journal of Vision 2009;9(14):41.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

The melanopsin photopigment is an opsin class of G-protein coupled receptor (GPCR) playing a key role in the regulation of nonvisual photic responses. Upon activation, most mammalian GPCRs are phosphorylated in the C-terminal region by G-protein receptor kinases, which serve to recruit arrestin. Arrestin-binding often competes with G-protein for GPCR interaction and constitutes the mechanism of deactivation. We previously showed that ectopically expressed melanopsin produced a photocurrent in Xenopus oocytes supplemented with all-trans retinal in the presence of beta-arrestin. To understand the regulation of melanopsin function, here we investigated the role of arrestin. Photoactivated melanopsin was Ser/Thr phosphorylated at multiple sites in its C-terminal region. Deletion of this region did not affect photoactivation of melanopsin but attenuated the arrestin dependent deactivation. We propose that arrestin plays an important role in the deactivation of melanopsin by binding to the phosphorylated C-terminal region of melanopsin.

Hatori, M. Panda, S. (2009). The role of arrestin In melanopsin function [Abstract]. Journal of Vision, 9(14):41, 41a,, doi:10.1167/9.14.41. [CrossRef]

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.