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Raika Pancaroglu, Samantha Johnston, Alla Sekunova, Bradley Duchaine, Jason JS Barton; Prosopagnosia Following Epilepsy Surgery: What You See Is Not All They Have. Journal of Vision 2012;12(9):489. doi: https://doi.org/10.1167/12.9.489.
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© ARVO (1962-2015); The Authors (2016-present)
Background: Studies of acquired prosopagnosia suggest that occipitotemporal lesions involving the fusiform gyrus are associated with perceptual deficits in face processing, while anterior temporal lesions are associated with associative or amnestic deficits, and that these lesions are right dominant. Surgical procedures for epilepsy can cause prosopagnosia in rare cases; however, the utility of their surgical lesions for structure-function correlations is uncertain, because by selection these patients have pre-operative focal neurological anomalies.
Objective: We describe two cases of prosopagnosia following epilepsy surgery, in whom we located their surgical lesions and characterized their face processing networks, and related this to behavioural results in a structure-function correlation study. Method: Subjects had structural and functional MRI using a sensitive dynamic face localizer to find ROIs and characterize the status of their core face network (fusiform face area, FFA, occipital face area, OFA, and superior temporal sulcus, STS). In a perceptual battery, we evaluated face detection, face recognition, face perception, face imagery, and semantic knowledge about people. Subjects also underwent event-related potential to characterize the face-selective N170. Results: Subject R-AT1 had a right amygdalo-hippocampectomy sparing the core face network. Unlike other subjects with right anterior temporal lesions after trauma or encephalitis, she was impaired in face detection and perception, and had an anomalous N170 potential. Subject L-IOT1 became prosopagnosic after resection of the left fusiform gyrus and was impaired in face detection and perception. However, MRI also showed that the right fusiform gyrus was atrophic and did not show activation to faces. He was also impaired in semantic knowledge of people. Conclusion: Prosopagnosia following epilepsy surgery may reflect the effects of not only the surgical lesion but also pre-operative cerebral anomalies, resulting in more widespread functional deficits than predicted by their surgical lesion.
Meeting abstract presented at VSS 2012
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