December 2014
Volume 14, Issue 15
OSA Fall Vision Meeting Abstract  |   December 2014
Retino-cortical relationships in albinism
Author Affiliations
  • Melissa Wilk
    Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin
  • Jedidiah Mathis
    Radiology, Medical College of Wisconsin
  • C. Gail Summers
    Opthalmology & Visual Neurosciences, University of Minnesota
  • Alfredo Dubra
    Ophthalmology, Medical College of Wisconsin
  • Joseph Carroll
    Ophthalmology, Medical College of Wisconsin
  • Edgar DeYoe
    Radiology, Medical College of Wisconsin
Journal of Vision December 2014, Vol.14, 51. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Melissa Wilk, Jedidiah Mathis, C. Gail Summers, Alfredo Dubra, Joseph Carroll, Edgar DeYoe; Retino-cortical relationships in albinism. Journal of Vision 2014;14(15):51.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Introduction: Albinism is a disorder of melanin synthesis that results in variable visual function. However, retinal disruptions in albinism do not fully explain the loss of visual acuity. While abnormal decussation of retinal afferents and disrupted retinotopic organization are known features of albinism, the role of cortical structure in establishing visual function in patients with albinism is poorly characterized. Understanding these aspects of the visual system will provide insight into the visual deficits associated with albinism. Methods: Two patients with oculocutatneous albinism 1B (OCA1B) underwent adaptive optics (AO) retinal imaging and functional magnetic resonance imaging (fMRI). Cortical maps were examined for abnormal retinotopy. In addition, cone density and cortical magnification were quantified over a 20 degree eccentricity. Results: Each patient exhibited a unique retinotopic map. Cortical magnification functions did not match cone density functions. Correction for cone-to-ganglion cell convergence at varying eccentricities showed a better, yet not complete, match between ganglion cell density functions and cortical magnification. Conclusion: Our results suggest that there is more variation in cortical organization in human albinism than is suggested by current conceptualizations. Additionally, disruptions to cortical magnification are not predicted by cone density alone. The cortical magnification, however, can be better predicted when accounting for convergence of visual neurons, but more subjects are needed to better delineate these relationships.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.