December 2014
Volume 14, Issue 15
OSA Fall Vision Meeting Abstract  |   December 2014
Looking at vision and behavior in mouse visual cortex
Author Affiliations
  • Matteo Carandini
    University College London
Journal of Vision December 2014, Vol.14, 6. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Matteo Carandini; Looking at vision and behavior in mouse visual cortex. Journal of Vision 2014;14(15):6.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Most of what we know on primary visual cortex (V1) comes from experiments performed while animals are static, often under anesthesia. Yet visual cortex is typically used by awake animals while they actively navigate an environment. We are therefore studying how visual processing in mouse V1 is affected by wakefulness, locomotion, and navigation. Our results indicate that wakefulness enhances synaptic inhibition, abolishing the balance of excitation and inhibition typically seen in V1 under anesthesia. Inhibition, or rather disinhibition, plays a particularly strong role during locomotion: it profoundly alters spatial integration, reducing the surround suppression that is common in V1 neurons of stationary animals. Finally, navigation powerfully modulates V1 signals, in a way that is ideally suited to code for the visual stimuli created by locomotion in the environment. These results indicate that visual processing in mouse V1 is profoundly affected by wakefulness, locomotion, and navigation, providing clues as to how sensory cortex integrates external signals that come from the environment with internal signals about brain and behavioral state.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.