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Wei Wei, Qiang Chen, David Koren; Neural mechanisms of direction selectivity in the retina. Journal of Vision 2016;16(12):929. doi: https://doi.org/10.1167/16.12.929.
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© ARVO (1962-2015); The Authors (2016-present)
The direction selective circuit in the retina computes motion directions and conveys this information to higher brain areas via the spiking activity of direction selective ganglion cells. While multiple synaptic mechanisms have been implicated in the generation of direction selectivity in the retina, it is unclear how individual mechanism modulates the firing patterns of direction selective ganglion cells. Here, we aim to unambiguously differentiate the contributions of distinct circuit components to direction selectivity by loss-of-function studies using genetic, electrophysiological and functional imaging methods. Our results highlight the concerted actions of synaptic and cell-intrinsic mechanisms required for robust direction selectivity in the retina, and provide critical insights into how patterned excitation and inhibition collectively implement sensory processing in the brain.
Meeting abstract presented at VSS 2016
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