August 2016
Volume 16, Issue 12
Open Access
Vision Sciences Society Annual Meeting Abstract  |   September 2016
A unique Go/No-go task reveals specific inhibition-related activation in the right IPS
Author Affiliations
  • Tamar Kolodny
    Department of Cognitive Sciences, the Hebrew University of Jerusalem
  • Pnina Stern
    Constantiner School of Education, Tel Aviv University
  • Maya Ankaoua
    Sagol School of Neuroscience, Tel Aviv University
  • Natalie Kataev
    School of Psychology, Tel Aviv University
  • Carmel Mevorach
    School of Psychology, University of Birmingham, UK
  • Lilach Shalev
    Constantiner School of Education, Tel Aviv University
Journal of Vision September 2016, Vol.16, 609. doi:
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      Tamar Kolodny, Pnina Stern, Maya Ankaoua, Natalie Kataev, Carmel Mevorach, Lilach Shalev; A unique Go/No-go task reveals specific inhibition-related activation in the right IPS . Journal of Vision 2016;16(12):609.

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      © ARVO (1962-2015); The Authors (2016-present)

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Introduction: Response inhibition - the ability to suppress inadequate but pre-potent response tendencies - is a cognitive-motor effortful process, in the realm of cognitive control. Interestingly, impaired response inhibition has been suggested as a key component in disorders such as ADHD. However, the brain mechanisms typically reported for response inhibition are extensive and provide poor markers for investigating atypicalities. Methods: We used rapid event-related functional magnetic resonance imaging (fMRI) to investigate the neural mechanisms underlying response inhibition in healthy controls. Participants performed a novel Go/No-go task that minimizes intervening factors such as perceptual complexity and working memory, while emphasizing attentional components. Manipulation of the frequency of targets, from 25% to 75%, enabled us to create a contrast of No-go trials at different frequencies. This contrast is expected to isolate inhibition-related activity while eliminating the involvement of motor, perceptual and working memory components. Results and discussion: Unlike previous reports, which in most cases contrasted No-go trials with Go trials and yielded activations in widespread fronto-parietal networks, our unique design allowed us to isolate a distinct cluster of activation in the right intraparietal sulcus (rIPS). Our findings suggest that the rIPS may serve as a potential neuroanatomical marker for response inhibition. In future studies we will utilize this marker, comparing the neural response in participants with and without ADHD, and investigating the relation of this focal activity to behavioural measures and symptomatology of attention deficits.

Meeting abstract presented at VSS 2016


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