High speed adaptive optics parallel confocal ophthalmoscopy

Abstract

To improve the image acquisition efficiency of high resolution adaptive optics (AO) confocal ophthalmoscopy and counter the image distortion induced by continuous and rapid eye movement, we have developed a high speed AO parallel confocal ophthalmoscope (AOPCO). This instrument employs a digital micromirror device to modulate the imaging light into a line of point sources, illuminating the retina simultaneously. By using a high speed line camera to acquire the image and AO to compensate ocular wave aberration, the AOPCO can image the living human eye with cellular level resolution at the frame rate of 200 Hz with a digitization of 768×512 pixels/frame over a field of view of 1.93 × 1.28 degrees. We demonstrate the ability for reducing even eliminating the spatial distortion of retinal imaging caused by involuntary fixational eye movements and the potential for investigating fast moving features like erythrocytes through the retinal vasculature in the living human eye.

Meeting abstract presented at the 2016 OSA Fall Vision Meeting

Footnotes

 Supported by National Institutes of Health (NIH) (EY021903, EY024378, P30 EY003039). National Science Foundation (NSF) (IIA-1539034); Institutional support from Research to Prevent Blindness and EyeSight Foundation of Alabama.