September 2018
Volume 18, Issue 10
Open Access
Vision Sciences Society Annual Meeting Abstract  |   September 2018
The population mean pupil response to melanopsin stimulation is reliable across sessions and background light levels
Author Affiliations
  • Harrison McAdams
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania
  • Aleksandra Igdalova
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania
  • Manuel Spitschan
    Department of Psychology, University of Pennsylvania
  • David Brainard
    Department of Psychology, University of Pennsylvania
  • Geoffrey Aguirre
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania
Journal of Vision September 2018, Vol.18, 878. doi:10.1167/18.10.878
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Harrison McAdams, Aleksandra Igdalova, Manuel Spitschan, David Brainard, Geoffrey Aguirre; The population mean pupil response to melanopsin stimulation is reliable across sessions and background light levels. Journal of Vision 2018;18(10):878. doi: 10.1167/18.10.878.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

We examined if the pupil response to melanopsin stimulation differs from that to cone stimulation, and if these pupil responses are stable in a healthy population. Following a pre-registered protocol (https://osf.io/76u9x/), we measured the pupil response to 3-second unipolar spectral pulses in each of 24 people during two separate sessions. These were designed to selectively stimulate either melanopsin (Mel) or the L, M, and S cones (LMS). The pulses produced 400% nominal contrast upon the targeted retinal mechanism and were presented against a rod-saturating background (~100 cd/m2 for Mel, ~40 cd/m2 for LMS). The group average shape of pupil constriction expressed as percentage change from baseline for each stimulus was highly consistent from the first to second session, suggesting that the pupil response is reproducible in a healthy population (Mel r = 0.995; LMS r = 0.999). We quantified the temporal dynamics of the pupil response. This revealed that the pupil response to Mel stimulation was prolonged relative to that of LMS stimulation. 21 subjects underwent a third pupillography session identical in structure to the first two except at higher light levels (background luminance for Mel and LMS pulses were increased to ~270 and ~100 cd/m2 respectively). The shape of the group average response (expressed in percentage change) to Mel and LMS stimulation was again highly overlapping with the responses from the first two sessions (Mel r = 0.994; LMS r = 0.999), suggesting that these pupil responses are independent of background light level. We find the pupil response to selective melanopsin stimulation is highly stable in a healthy population, and that the temporal dynamics of the Mel-driven response differ from those of the LMS-driven response. This high degree of reproducibility suggests that tests for clinical differences in response will be well powered with a reasonable number of subjects.

Meeting abstract presented at VSS 2018

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×