September 2018
Volume 18, Issue 10
Open Access
Vision Sciences Society Annual Meeting Abstract  |   September 2018
Chronotopic maps in human premotor cortex
Author Affiliations
  • Foteini Protopapa
    International School for Advanced Studies (SISSA), Trieste, Italy.
  • Masamichi Hayashi
    Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.School of Psychology, University of Sussex, Brighton, United Kingdom.
  • Wietske van der Zwaag
    Spinoza Centre for Neuroimaging, Amsterdam, Netherlands.
  • Giovanni Battistella
    Icahn School of Medicine at Mount Sinai, New York, USA.Centre hospitalier universitaire vaudois (CHUV) University Hospital of Lausanne, Switzerland.
  • Micah Murray
    Vanderbilt University, Department of Hearing and Speech Sciences, Nashville, USA.University of Lausanne, Division of Neuropsychology and Rehabilitation, Lausanne, Switzerland.
  • Ryota Kanai
    Araya, Inc., Tokyo, JapanSackler Centre for Consciousness Science, University of Sussex, Brighton, UK.
  • Domenica Bueti
    International School for Advanced Studies (SISSA), Trieste, Italy.
Journal of Vision September 2018, Vol.18, 963. doi:10.1167/18.10.963
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      Foteini Protopapa, Masamichi Hayashi, Wietske van der Zwaag, Giovanni Battistella, Micah Murray, Ryota Kanai, Domenica Bueti; Chronotopic maps in human premotor cortex. Journal of Vision 2018;18(10):963. doi: 10.1167/18.10.963.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Time is the most elusive dimension of everyday experiences. We cannot see or touch time nevertheless we clearly sense its flow and adjust our behavior accordingly. The neuronal mechanism underlying our capacity to perceive time remains yet unknown. Single-neuron recordings in animals suggest that the encoding of temporal information in the millisecond/second range is achieved via duration tuning mechanisms. The existence of such mechanisms has never been reported in the human brain. Here, in two independent visual duration-discrimination experiments, using ultra-high-field (7-Tesla) functional magnetic resonance imaging, we found duration-related activations in the medial premotor cortex and the posterior parts of the left parietal lobule of the human brain. More specifically, in the supplementary motor area (SMA), we identified a topographic organization of duration selective voxels i.e., chronotopic maps. Voxels sensitive to the shortest duration were mainly located in the anterior premotor cortex while those responsive to the longest duration in the posterior premotor cortex. This rostro-caudal direction of chronotopic organization was consistent in both experiments. We also showed that the hemodynamic response of each portion of the chronotopic map was enhanced by the preferred and its' neighboring durations and inhibited by non-preferred durations represented in distant portions of the map. These findings identify, for the first time in the human brain, duration-sensitive tuning as a neural mechanism underlying the active recognition of time and demonstrate that the adaptive representation of an abstract feature such as time can be achieved by a topographical arrangement of duration-sensitive neural populations similar to that observed in several cortical and subcortical structures for the processing of sensory and motor signals.

Meeting abstract presented at VSS 2018

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