September 2018
Volume 18, Issue 10
Open Access
Vision Sciences Society Annual Meeting Abstract  |   September 2018
Human Melanopic Circuit in Isolation from Photoreceptor Input:Light Sensitivity and Temporal Profile
Author Affiliations
  • Artur Cideciyan
    Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania
Journal of Vision September 2018, Vol.18, 1347. doi:10.1167/18.10.1347
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Artur Cideciyan; Human Melanopic Circuit in Isolation from Photoreceptor Input:Light Sensitivity and Temporal Profile. Journal of Vision 2018;18(10):1347. doi: 10.1167/18.10.1347.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Leber congenital amaurosis refers to a group of severe early-onset inherited retinopathies. There are more than 20 causative genes with varied pathophysiological mechanisms resulting in vision loss at the level of the photoreceptors. Some eyes retain near normal photoreceptor and inner retinal structure despite the severe retina-wide loss of photoreceptor function. High luminance stimuli allow recording of pupillary responses driven directly by melanopsin-expressing intrinsically photosensitive retinal ganglion cells. Analyses of these pupillary responses help clarify the fidelity of transmission of light signals from the retina to the brain for patients with no light perception undergoing early phase clinical treatment trials. In addition, these responses serve to define the sensitivity and temporal profile of the human melanopic circuit in isolation from photoreceptor input.

Meeting abstract presented at VSS 2018

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×