December 2019
Volume 19, Issue 15
Open Access
OSA Fall Vision Meeting Abstract  |   December 2019
Effect of Visual Training on Optic Tract Degeneration after V1 Lesions
Author Affiliations
  • Berkeley K. Fahrenthold
    Flaum Eye Institute, University of Rochester Medical Center
  • Matthew R. Cavanaugh
    Flaum Eye Institute, University of Rochester Medical Center
  • Allison Murphy
    Department of Neuroscience, University of Rochester Medical Center
  • Sara Ajina
    Nuffield Department of Clinical Neurosciences, University of Oxford
  • Arash Sahraie
    School of Psychology, University of Aberdeen
  • Holly Bridge
    Nuffield Department of Clinical Neurosciences, University of Oxford
  • Krystel R. Huxlin
    Flaum Eye Institute, Center for Visual Science, University of Rochester Medical Center
Journal of Vision December 2019, Vol.19, 35. doi:
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      Berkeley K. Fahrenthold, Matthew R. Cavanaugh, Allison Murphy, Sara Ajina, Arash Sahraie, Holly Bridge, Krystel R. Huxlin; Effect of Visual Training on Optic Tract Degeneration after V1 Lesions. Journal of Vision 2019;19(15):35. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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Damage to the primary visual cortex causes a contralateral visual field defect known as cortical blindness (CB). While some vision can recover spontaneously in the first few months post-insult1, without intervention, a slow, progressive loss of vision characterizes the ensuing months and years2,3. Trans-synaptic retrograde degeneration4–7 may explain this progressive loss, which in humans, manifests by reduced optic tract (OT) size ipsilateral to the lesion8. Given that visual training can reduce the size of visual deficits months to years after occipital stroke9, we asked here if visual training slows or stops this degeneration. As such, we measured optic tract volume in 31 chronic (>6 months post-stroke) cortically blind patients, 17 of whom underwent visual training. About half of the subjects (17/31) exhibited significant OT shrinkage on the side of the lesion, resulting in a positive laterality index (LI), while the remaining 14/31 exhibited similar left and right OT volumes (LI=0). Training-induced visual recovery did not decrease LI, or prevent LI from getting worse in those who had LI=0 pre-training. However, there was a negative correlation between pre-training LI and visual field shrinkage post-training (R2=0.5, p = 0.019). Our results suggest significant heterogeneity in OT shrinkage after V1 stroke, which progresses irrespective of visual training in the chronic period. However, importantly it appears that pre-training LI predicts the magnitude of visual field recovery achievable with visual training in chronic CB, with patients whose LI was 0 before training exhibiting the greatest amount of visual field recovery.

Zhang, X., Kedar, S., Lynn, M. J., Newman, N. J., Biousse, V. Homonymous Hemianopia in Stroke J. Neuroophthalmol. 26 180 2006 [CrossRef] [PubMed]
Cavanaugh, M. R., & Huxlin, K. R. Visual discrimination training improves Humphrey perimetry in chronic cortically induced blindness Neurology 88 1856-1864 2017 [CrossRef] [PubMed]
Wang, V., Saionz, E., Cavanaugh, M., Huxlin, K. Natural progression of perimetric visual field defects after V1 stroke J. Vis. 17 51-52 2017 [CrossRef]
Cowey, A., Alexander, I., Stoerig, P. Transneuronal retrograde degeneration of retinal ganglion cells and optic tract in hemianopic monkeys and humans Brain 134 2149-2157 2011 [CrossRef] [PubMed]
Atapour, N., Worthy, K. H., Lui, L. L., Yu, H.-H., Rosa, M. G. P. Neuronal degeneration in the dorsal lateral geniculate nucleus following lesions of primary visual cortex: comparison of young adult and geriatric marmoset monkeys Brain Struct. Funct. 222 3283-3293 2017 [CrossRef] [PubMed]
Jindahra, P., Petrie, A., Plant, G. T. Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography Brain 132 628-634 2009 [CrossRef] [PubMed]
Jindahra, P., Petrie, A., Plant, G. T. The time course of retrograde trans-synaptic degeneration following occipital lobe damage in humans Brain J. Neurol. 135 534-541 2012 [CrossRef]
Bridge, H., Jindahra, P., Barbur, J., Plant, G. T. Imaging Reveals Optic Tract Degeneration in Hemianopia Invest. Ophthalmol. Vis. Sci. 52 382-388 2011 [CrossRef] [PubMed]
Melnick, M. D., Tadin, D., Huxlin, K. R. Relearning to See in Cortical Blindness The Neuroscientist 22 199-212 2016 [CrossRef] [PubMed]

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