September 2021
Volume 21, Issue 9
Open Access
Vision Sciences Society Annual Meeting Abstract  |   September 2021
Comparing stimulus-evoked and spontaneous responses of face-selective multi-units in humans
Author Affiliations
  • Rina Schwartz
    The Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    Department of Psychology, Bar-Ilan University, Ramat Gan, Israel
  • Camille Rozier
    Institut National de la Santé et de la Recherche Médicale Unité 1127, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 7225, Université Pierre-et-Marie-Curie Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Épinière ICM, 75013 Paris, France
  • Tal Seidel Malkinson
    Institut National de la Santé et de la Recherche Médicale Unité 1127, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 7225, Université Pierre-et-Marie-Curie Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Épinière ICM, 75013 Paris, France
  • Katia Lehongre
    Institut National de la Santé et de la Recherche Médicale Unité 1127, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 7225, Université Pierre-et-Marie-Curie Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Épinière ICM, 75013 Paris, France
    Centre de NeuroImagerie de Recherche–CENIR, Institute of Brain and Spine, UMRS 1127, CNRS UMR 7225, Pitié-Salpêtriere Hospital, Paris, France
  • Claude Adam
    AP-HP, GH Pitie-Salpêtrière Charles Foix, Epilepsy Unit and Neurophysiology Department, Paris, France
  • Virginie Lambrecq
    Institut National de la Santé et de la Recherche Médicale Unité 1127, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 7225, Université Pierre-et-Marie-Curie Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Épinière ICM, 75013 Paris, France
    AP-HP, GH Pitie-Salpêtrière Charles Foix, Epilepsy Unit and Neurophysiology Department, Paris, France
  • Vincent Navarro
    Institut National de la Santé et de la Recherche Médicale Unité 1127, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 7225, Université Pierre-et-Marie-Curie Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Épinière ICM, 75013 Paris, France
    AP-HP, GH Pitie-Salpêtrière Charles Foix, Epilepsy Unit and Neurophysiology Department, Paris, France
    Sorbonne Université, UMR S1127, F-75013, Paris, France
  • Lionel Naccache
    Institut National de la Santé et de la Recherche Médicale Unité 1127, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 7225, Université Pierre-et-Marie-Curie Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle Épinière ICM, 75013 Paris, France
    AP-HP, Groupe hospitalier Pitié-Salpêtrière, Department of Neurology, Department of Neurophysiology, 75013, Paris, France
  • Vadim Axelrod
    The Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel
Journal of Vision September 2021, Vol.21, 2235. doi:https://doi.org/10.1167/jov.21.9.2235
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    • Get Citation

      Rina Schwartz, Camille Rozier, Tal Seidel Malkinson, Katia Lehongre, Claude Adam, Virginie Lambrecq, Vincent Navarro, Lionel Naccache, Vadim Axelrod; Comparing stimulus-evoked and spontaneous responses of face-selective multi-units in humans. Journal of Vision 2021;21(9):2235. https://doi.org/10.1167/jov.21.9.2235.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The face-selective response in the human occipito-temporal cortex has been extensively explored at the level of large neural populations (e.g., using functional MRI [fMRI], electroencephalography / magnetoencephalography, or intracranial local field potential), but not at the level of single or multi-units. We have recently reported a rare case of two face-selective units located in the vicinity of the Fusiform Face Area, recorded from a patient with epilepsy (Axelrod et al., 2019, Neurology). These units exhibited a robust (300% and more) modulation for a variety of facial stimuli. In addition to the stimulus-evoked response, it is well established that neurons also fire spontaneously, without any task. Notably, the degree of similarity between the magnitudes of stimulus-evoked activity and spontaneous activity is still unclear. In the present study we capitalized on a rare face-selective multi-unit recording from a human subject, to compare stimulus-evoked activity elicited by static images of faces and spontaneous activity recorded during a 6-minute continuous resting-state session. We found that generally, the magnitude of the face-selective stimulus-evoked response was much greater than the magnitude of spontaneous activity. However, this difference also depended on the duration of the time-window (i.e. a period of interest) utilized to examine the response. In particular, for time-windows of 150 ms and more, there were few spontaneous responses with comparable firing rates to those found in the face-selective evoked response. However, for shorter periods of interest (e.g. 50 ms), when comparing an equal number of windows, about 10-20% of the firing rates recorded during spontaneous activity were comparable to those recorded during the face-selective stimulus-evoked response. Overall, the present results provide a unique perspective on the relationship between stimulus-evoked and spontaneous neural activity.

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