February 2022
Volume 22, Issue 3
Open Access
Optica Fall Vision Meeting Abstract  |   February 2022
Boynton Award Lecture: Cone resilience, rod vulnerability - how precise retinal topography will help beat age-related macular degeneration
Author Affiliations
  • Christine A. Curcio
    Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham
Journal of Vision February 2022, Vol.22, 59. doi:https://doi.org/10.1167/jov.22.3.59
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      Christine A. Curcio; Boynton Award Lecture: Cone resilience, rod vulnerability - how precise retinal topography will help beat age-related macular degeneration. Journal of Vision 2022;22(3):59. doi: https://doi.org/10.1167/jov.22.3.59.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

AMD is both the most prevalent disease with a CNS neurodegeneration and the most approachable due to the precision and in vivo visibility of photoreceptors and their support cells and very large biological effects. We hypothesize that a center of cone resilience due to xanthophyll carotenoids in foveal Müller glia overlies a larger surround of rod vulnerability due to age-related lipidization of Bruch’s membrane and choriocapillary endothelium degeneration. A timeline of disease progression is in view for drusen-driven disease, across the lifespan and aligning spatially on the biology of foveal cone vision. Rods elucidate the next chapter of deposit-driven AMD end-stages as well as a new neuroscience for lysosome-related organelles in the retinal pigment epithelium.

Footnotes
 Funding: None
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