February 2022
Volume 22, Issue 3
Open Access
Optica Fall Vision Meeting Abstract  |   February 2022
Invited Session II: Retinal mechanisms mediating vision: The S-cone connectome of the primate retina
Author Affiliations
  • Sara S. Patterson
    Center for Visual Science, University of Rochester, Rochester, NY
Journal of Vision February 2022, Vol.22, 47. doi:https://doi.org/10.1167/jov.22.3.47
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      Sara S. Patterson; Invited Session II: Retinal mechanisms mediating vision: The S-cone connectome of the primate retina. Journal of Vision 2022;22(3):47. doi: https://doi.org/10.1167/jov.22.3.47.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Trichromatic humans have three types of cone photoreceptor: L-, M- and S-cones, which are tuned to long-, medium- and short-wavelength light, respectively. We know the least about the pathways carrying signals from S-cones because they are very rare and make up less than 10% of all cones. Past research has focused primarily on small bistratified ganglion cells that compare the outputs of S-cones to the summed outputs of L- and M-cones (S vs. L+M). I will review our recent efforts to comprehensively map S-cone circuitry within the macaque central retina using serial block-face scanning electron microscopy. We identified a surprising diversity of S-cone ON and OFF pathways, each with the same spectral signature: S vs. L+M. In total, the primate retina conveys this one spectral signal to the brain along at least five parallel pathways. Our results challenge classic color vision models that can only account for a single S vs. L+M pathway and demonstrate how our visual systems use color information for far more than just color perception.

Footnotes
 Funding: F32-EY032318, R01-EY027859, P30-EY001730
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