February 2022
Volume 22, Issue 3
Open Access
Optica Fall Vision Meeting Abstract  |   February 2022
Contributed Session II: Motion/direction-sensitive thalamic neurons project extensively to the middle layers of primary visual cortex
Author Affiliations
  • Jun Zhuang
    Allen Institute for Brain Science
  • Yun Wang
    Allen Institute for Brain Science
  • Naveen D. Ouellette
    Allen Institute for Brain Science
  • Emily Turschak
    Allen Institute for Brain Science
  • Rylan S. Larsen
    Allen Institute for Brain Science
  • Kevin T. Takasaki
    Allen Institute for Brain Science
  • Tanya L. Daigle
    Allen Institute for Brain Science
  • Bosiljka Tasic
    Allen Institute for Brain Science
  • Jack Waters
    Allen Institute for Brain Science
  • Hongkui Zeng
    Allen Institute for Brain Science
  • R. Clay Reid
    Allen Institute for Brain Science
Journal of Vision February 2022, Vol.22, 16. doi:https://doi.org/10.1167/jov.22.3.16
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      Jun Zhuang, Yun Wang, Naveen D. Ouellette, Emily Turschak, Rylan S. Larsen, Kevin T. Takasaki, Tanya L. Daigle, Bosiljka Tasic, Jack Waters, Hongkui Zeng, R. Clay Reid; Contributed Session II: Motion/direction-sensitive thalamic neurons project extensively to the middle layers of primary visual cortex. Journal of Vision 2022;22(3):16. doi: https://doi.org/10.1167/jov.22.3.16.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The motion/direction-sensitive and location-sensitive neurons are two major functional types in mouse visual thalamus that project to the primary visual cortex (V1). It has been proposed that the motion/direction-sensitive neurons mainly target the superficial layers in V1, in contrast to the location-sensitive neurons which mainly target the middle layers. Here, by imaging calcium activities of motion/direction-sensitive and location-sensitive axons in V1, we find no evidence for these cell-type specific laminar biases at population level. Furthermore, using a novel approach to reconstruct single-axon structures with identified in vivo response types, we show that, at single-axon level, the motion/direction-sensitive axons have middle layer preferences and project more densely to the middle layers than the location-sensitive axons. Overall, our results demonstrate that Motion/direction-sensitive thalamic neurons project extensively to the middle layers of V1, challenging the current view of the thalamocortical organizations in the mouse visual system.

Footnotes
 Funding: NINDS R01NS104949, NIMH R01MH117820
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