February 2022
Volume 22, Issue 3
Open Access
Optica Fall Vision Meeting Abstract  |   February 2022
Contributed Session II: Tissue properties of optic radiations representing the foveal and peripheral visual fields
Author Affiliations
  • John Kruper
    Department of Psychology, University of Washington, USA eScience Institute, University of Washington, USA
  • Noah C. Benson
    eScience Institute, University of Washington, USA
  • Sendy Caffarra
    Graduate School of Education and Department of Pediatrics, Stanford, USA
  • Julia Owen
    Department of Ophthalmology, University of Washington, USA
  • Yue Wu
    Department of Ophthalmology, University of Washington, USA
  • Aaron Lee
    Department of Ophthalmology, University of Washington, USA
Journal of Vision February 2022, Vol.22, 15. doi:https://doi.org/10.1167/jov.22.3.15
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      John Kruper, Noah C. Benson, Sendy Caffarra, Julia Owen, Yue Wu, Aaron Lee; Contributed Session II: Tissue properties of optic radiations representing the foveal and peripheral visual fields. Journal of Vision 2022;22(3):15. doi: https://doi.org/10.1167/jov.22.3.15.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The biological properties of the foveal and peripheral visual pathways differ substantially. Here, we compared tissue properties of optic radiations (OR) carrying foveal and peripheral information to primary visual cortex (V1), measured with diffusion MRI (dMRI). We analyzed dMRI in two datasets: the Human Connectome Project (HCP; n=180; age 22-35) and the UK Biobank (UKB; n=7,088; age 45-81). In the HCP, OR was delineated using a three-dimensional atlas; parts of OR representing fovea and periphery were divided based on V1 fMRI responses close to OR endpoints. (2) In the UKB, OR was delineated using landmarks and divided using anatomically-based estimates of V1 responses close to OR endpoints. The dMRI signal was modeled using a kurtosis model, which provides information about tissue microstructure. Despite differences in data collection, population characteristics, and analysis methods, both datasets revealed higher fractional anisotropy, lower mean diffusivity, and higher mean kurtosis in the foveal OR than in peripheral OR, consistent with denser nerve fiber populations in foveal pathways. In further analysis of the UKB, we found that age is associated with increased diffusivity and decreased anisotropy and kurtosis, consistent with decreased density and tissue organization with aging. However, anisotropy in fovea decreases faster with age than in periphery, while diffusivity increases faster in periphery, suggesting foveal and peripheral OR differ in terms of aging.

Footnotes
 Funding: Unrestricted and career development award from RPB, NEI/NIH K23EY029246 and NIA/NIH U19AG066567. AFQ projects supported through grant 1RF1MH121868-01 from the NIMH/The BRAIN Initiative.
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