February 2022
Volume 22, Issue 3
Open Access
Optica Fall Vision Meeting Abstract  |   February 2022
Contributed Session I: A Multi-Modal Visual Assessment System For Monitoring Spaceflight Associated Neuro-Ocular Syndrome (SANS) During Long Duration Spaceflight
Author Affiliations
  • Joshua Ong
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Nasif Zaman
    Human-Machine Perception Laboratory, Department of Computer Science and Engineering, University of Nevada, Reno, Reno, Nevada, United States
  • Sharif Amit Kamran
    Human-Machine Perception Laboratory, Department of Computer Science and Engineering, University of Nevada, Reno, Reno, Nevada, United States
  • Ethan Waisberg
    University College Dublin School of Medicine, Belfield, Dublin, Ireland
  • Alireza Tavakkoli
    Human-Machine Perception Laboratory, Department of Computer Science and Engineering, University of Nevada, Reno, Reno, Nevada, United States
  • Andrew G. Lee
    Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas, United States
    Center for Space Medicine, Baylor College of Medicine, Houston, Texas, United States
    The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, United States
    Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, New York, United States
    Department of Ophthalmology, University of Texas Medical Branch, Galveston, Texas, United States
    University of Texas MD Anderson Cancer Center, Houston, Texas, United States
    Texas A&M College of Medicine, Texas, United States
    Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
  • Michael Webster
    Department of Psychology, University of Nevada, Reno, United States
    Visual Perception Laboratory, University of Nevada, Reno, United States
Journal of Vision February 2022, Vol.22, 6. doi:https://doi.org/10.1167/jov.22.3.6
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      Joshua Ong, Nasif Zaman, Sharif Amit Kamran, Ethan Waisberg, Alireza Tavakkoli, Andrew G. Lee, Michael Webster; Contributed Session I: A Multi-Modal Visual Assessment System For Monitoring Spaceflight Associated Neuro-Ocular Syndrome (SANS) During Long Duration Spaceflight. Journal of Vision 2022;22(3):6. doi: https://doi.org/10.1167/jov.22.3.6.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Spaceflight Associated Neuro-Ocular Syndrome (SANS) refers to a unique collection of neuro-ophthalmic clinical and imaging findings that are observed in astronauts during long duration spaceflight. These findings include optic disc edema, posterior globe flattening, retinal nerve layer fiber thickening, optic nerve sheath distension, and hyperopic shift. SANS currently serves as a large barrier to deep space exploration; however, the exact pathophysiology is still being investigated. While in-flight imaging exists on the International Space Station, there are limitations to constant monitoring. To efficiently document the subtle changes that occur in SANS, NASA has funded the development of a head-mounted display, multi-modal visual assessment system; this novel device integrates visual acuity, visual field, contrast sensitivity, and metamorphopsia data (indirect indications) with known terrestrial neuro-ophthalmic imaging (direct indications) from astronauts and terrestrial analogs. By mapping these two indications, this visual assessment device will provide rapid in-flight monitoring of SANS symptoms and provide tools for the terrestrial development of countermeasures. We are in the process of beginning a pilot study of this multi-modal visual assessment device in healthy subjects to investigate the validity and reliability of this novel technology. This foundational study will compare the system with standard vision assessments utilized in clinical practice.

Footnotes
 Funding: This research was funded by NASA Grant 80NSSC20K1831 titled: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.
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