Longitudinal structural and functional changes in Central Serous Chorioretinopathy: A ten-year multimodal imaging-based study

Abstract

Purpose : To analyze the longitudinal changes in functional and imaging parameters in eyes with acute or chronic central serous chorioretinopathy (CSCR) over a minimum of 10 years.

Methods : This was a retrospective, multicentric, longitudinal, observational study in patients with a diagnosis of unilateral or bilateral CSCR. Trend in best-corrected visual acuity (BCVA), choroidal thickness (CT), area of double-layer sign (DLS), area of retinal pigment epithelium (RPE) alterations, and area of hyper-autofluorescence were analyzed.

Results : A total of 23 eyes of 16 patients (10 males and 6 females) were included in the study. The mean duration of symptoms prior to presentation was 20.6±50.6 months.
A slow worsening was seen in the chronic CSCR group, while it was relatively stable in the acute CSCR group (baseline 0.11±0.19 logMAR to final 0.08±0.13 logMAR in acute and baseline 0.31±0.47 to final 0.38±0.48 logMAR in chronic CSCR eyes). The trend in CT was more or less stable with a mild decrease in both acute and chronic CSCR groups over time (overall baseline 325±62.5 microns to final 314.8±71.8 microns). There was a slow rise in the area of RPE alteration and in a hyper-autofluorescent area in both acute and chronic CSCR with no overlap. However, there was a late dip in the values of hyper-auto-fluorescent areas. Duration of symptoms was significantly associated with poor final visual acuity in multivariate analysis.

Conclusions : Acute and chronic CSCR had different pattern of change in functional and imaging parameters. This could indicate a non-temporal relationship between acute and chronic CSCR forms.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Trend in visual acuity

 

Trend in imaging characteristics