December 2022
Volume 22, Issue 14
Open Access
Vision Sciences Society Annual Meeting Abstract  |   December 2022
Studies of visual neurophysiology in the psychosis Human Connectome Project
Author Affiliations & Notes
  • Michael-Paul Schallmo
    University of Minnesota, Minneapolis, MN
  • Kimberly Weldon
    University of Minnesota, Minneapolis, MN
  • Rohit Kamath
    University of Minnesota, Minneapolis, MN
  • Hannah Moser
    University of Minnesota, Minneapolis, MN
  • Samantha Montoya
    University of Minnesota, Minneapolis, MN
  • Kyle Killebrew
    University of Minnesota, Minneapolis, MN
  • Caroline Demro
    University of Minnesota, Minneapolis, MN
  • Andrea Grant
    University of Minnesota, Minneapolis, MN
  • Małgorzata Marjańska
    University of Minnesota, Minneapolis, MN
  • Scott Sponheim
    Veterans Affairs Medical Center, Minneapolis, MN
    University of Minnesota, Minneapolis, MN
  • Cheryl Olman
    University of Minnesota, Minneapolis, MN
  • Footnotes
    Acknowledgements  This work was supported by funding from the National Institutes of Health (U01 MH108150, K01 MH120278, R01 MH111447, P41 EB015894, P30 NS076408, UL1 TR002494).
Journal of Vision December 2022, Vol.22, 3364. doi:https://doi.org/10.1167/jov.22.14.3364
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      Michael-Paul Schallmo, Kimberly Weldon, Rohit Kamath, Hannah Moser, Samantha Montoya, Kyle Killebrew, Caroline Demro, Andrea Grant, Małgorzata Marjańska, Scott Sponheim, Cheryl Olman; Studies of visual neurophysiology in the psychosis Human Connectome Project. Journal of Vision 2022;22(14):3364. https://doi.org/10.1167/jov.22.14.3364.

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Abstract

People with psychosis spectrum disorders (e.g., schizophrenia) experience abnormal sensory percepts such as hallucinations and illusions (real stimuli are mis-perceived). Previous work has shown differences in visual task performance among people with psychosis across a wide range of paradigms. However, few neurophysiological studies have been conducted, and the neural basis of abnormal visual perception remains unclear. Because genetics play a significant role in psychosis, studying biological relatives may provide insight into phenotypes associated with genetic risk. The goal of the current study was to examine neurobiological markers of visual functioning among people with psychosis and their relatives to elucidate the neural mechanisms of abnormal visual perception. We acquired 7T functional MRI (fMRI), MR spectroscopy (MRS), and psychophysics data from three groups: people with psychosis (n = 58), their first-degree biological relatives (n = 43), and healthy controls (n = 38). Re-test scan data were acquired in 27 people with psychosis and 10 controls. We used 4 different visual paradigms: population receptive field mapping (fMRI only), contrast surround suppression (fMRI, psychophysics), contour object perception (fMRI, psychophysics), and structure-from-motion (psychophysics only). MR spectroscopy data were acquired in occipital and prefrontal regions at rest. This work was part of the psychosis Human Connectome Project (HCP), in which participants completed an HCP-style scanning protocol at 3T (T1 and T2 anatomy, resting state fMRI, diffusion MRI) in addition to 7T scans above. Both 3T and 7T scanning data will be made publicly available via NDA (Dec. 2022). Across over 750 psychophysical, fMRI, and MRS data sets, 89% passed all quality checks (e.g., catch trials, head motion, signal-to-noise). Significant differences between psychosis, relative, and control groups were observed across the various experimental conditions and visual paradigms. By making our data and methods publicly available, we hope to facilitate continued research into abnormal visual processing in psychosis.

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