August 2023
Volume 23, Issue 9
Open Access
Vision Sciences Society Annual Meeting Abstract  |   August 2023
Posterior parietal cortex damage causes endpoint biases relative to the visual target during anti-saccades
Author Affiliations & Notes
  • Julie Ouerfelli-Ethier
    University of Montreal
    Lyon Neuroscience Research Center, Trajectoires team
  • Romain Fournet
    University of Montreal
  • Laure Pisella
    Lyon Neuroscience Research Center, Trajectoires team
  • Aarlenne Khan
    University of Montreal
  • Footnotes
    Acknowledgements  This work was supported by the Natural Sciences and Engineer Research of Council, the Canada Research Chairs program, the Centre National de la Recherche Scientifique, and Labex/Idex
Journal of Vision August 2023, Vol.23, 5475. doi:
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      Julie Ouerfelli-Ethier, Romain Fournet, Laure Pisella, Aarlenne Khan; Posterior parietal cortex damage causes endpoint biases relative to the visual target during anti-saccades. Journal of Vision 2023;23(9):5475.

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      © ARVO (1962-2015); The Authors (2016-present)

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Anti-saccades are eye movements in which the saccade is executed in the opposite direction of a visual target. Because the visual target and saccade goal are decoupled, it has been suggested that competition between the two locations occurs and needs to be resolved. The posterior parietal cortex (PPC) has been implicated in anti-saccade production. To gain insight into the processes of competition and saccade planning within the PPC, we investigated anti-saccade performance in three patients with PPC lesions and 21 age-matched controls on three different anti-saccades paradigms: 90° away across hemifields, 90° away within the same hemifield and 180° away (diagonally opposite). Specifically, we examined how saccade endpoints demonstrated the extent of competition, i.e., the visual target’s interference with anti-saccade programming and execution processes. We observed that anti-saccade endpoints showed bias toward the visual target in all of control participants, and this appeared exacerbated in two of our patients. Our third patient showed, instead, a strong bias away from the visual target. Modified t-tests revealed a significant difference between two of patients and their controls in terms of amplitude relative to the visual target for the across and classic conditions, and no significant difference for the within condition. However, one patient showed no significant difference compared to controls across all conditions. Overall, we showed some evidence of a stronger bias relative to the visual target in our patients. This suggests that the PPC may contribute to competition resolution between visual target and saccade goal during anti-saccades.


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