September 2023
Volume 23, Issue 11
Open Access
Optica Fall Vision Meeting Abstract  |   September 2023
Poster Session: The impact of retinal excitotoxic lesions on parallel visual streams in the ferret dorsal lateral geniculate nucleus.
Author Affiliations
  • Jingyi Yang
    University of Rochester
  • Krystel Huxlin
    University of Rochester
  • Farran Briggs
    University of Rochester
Journal of Vision September 2023, Vol.23, 79. doi:https://doi.org/10.1167/jov.23.11.79
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      Jingyi Yang, Krystel Huxlin, Farran Briggs; Poster Session: The impact of retinal excitotoxic lesions on parallel visual streams in the ferret dorsal lateral geniculate nucleus. . Journal of Vision 2023;23(11):79. https://doi.org/10.1167/jov.23.11.79.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Attesting to the relative strength of retinal inputs to the dorsal lateral geniculate nucleus (LGN) of the thalamus, in cats, acute retinal lesions erase responses of LGN neurons whose receptive fields fall within the retinal lesion projection zone (LPZ). Yet, thirty days later, these receptive fields appear to shift their representation to the immediate surround of the LPZ. However, little is known about whether LGN neurons in parallel streams are equally affected following retinal damage. Here, we asked whether changes in response properties of surviving LGN neurons depend on (1) their identity as either X/Y or ON/OFF cells, or (2) their receptive fields’ positions relative to the LPZ. To test these hypotheses, we made retinal lesions by injecting kainic acid (KA) into one eye of ferrets and recorded from LGN neurons bilaterally in response to visual stimuli 7 days post-lesion. Area and eccentricities of retinal ganglion cell (RGC) loss in the retina were measured by RBPMS immunostaining. Relative eccentricities of recorded LGN neurons were based on electrode tracts. Our preliminary data suggest that RGC with large cell bodies are preserved in the lesioned eye. Additionally, we observed normal transient responses but altered sustained responses to flashing stimuli among contralateral responsive OFF LGN neurons. Together, these findings support the notion that acute KA lesions may differentially impact visual parallel processing streams at the surround of the LPZ in the LGN.

Footnotes
 Funding: Funding: EY031520
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